About: Respiratory virus detection in nasopharyngeal aspirate versus bronchoalveolar lavage is dependent on virus type in children with chronic respiratory symptoms

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About: Respiratory virus detection in nasopharyngeal aspirate versus bronchoalveolar lavage is dependent on virus type in children with chronic respiratory symptoms Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory virus detection in nasopharyngeal aspirate versus bronchoalveolar lavage is dependent on virus type in children with chronic respiratory symptoms
Creator	Sloots, Theo Chang, Anne Mackay, Ian Upham, John Wurzel, Danielle Yerkovich, Stephanie Clark, Julia Marchant, Julie Masters, I Wang, Claire Anderson-James, Sophie Baker, Peter
source	Elsevier; Medline; PMC
abstract	BACKGROUND: The comparative yield of respiratory virus detection from nasopharyngeal aspirate (NPA) versus bronchoalveolar lavage (BAL) is uncertain. Furthermore, the significance of virus detection and its relationship to lower airway neutrophilic inflammation is poorly studied. OBJECTIVES: To evaluate the sensitivity, specificity and predictive values of NPA for detecting respiratory viruses in BAL; and to determine the relationship between viruses and lower airway neutrophilia in children with non-acute respiratory illness. STUDY DESIGN: 150 paired NPA and BAL samples were obtained from 75 children aged <18 years undergoing flexible bronchoscopy for investigation of chronic respiratory symptoms. Viral studies were performed using polymerase chain reaction (PCR). Cellularity studies were performed on BALs. Diagnostic parameters of NPA compared to BAL and associations between viruses and lower airway %neutrophils were evaluated. RESULTS: NPA had a higher yield than BAL for detection of any respiratory virus (52 versus 38, respectively). NPA had a high sensitivity (92%) and low specificity (57%) for detecting HRV in BAL with poor kappa agreement value of 0.398 (95% CI 0.218–0.578, p < 0.001). NPA had a fair sensitivity (69%) and good specificity (90.3%) for detecting HAdV on BAL, kappa agreement was 0.561 (95% CI 0.321–0.801, p < 0.001). HAdV positivity on NPA, compared to negativity, was independently associated with heightened airway neutrophilia [mean difference (95% CI): 18 (1,35); p = 0.042]. CONCLUSIONS: NPA has a higher yield for respiratory virus detection than BAL, however its diagnostic accuracy is dependent on viral species. Adenovirus positivity is associated with significantly heightened lower airway neutrophilia in children with chronic respiratory symptoms.
has issue date	2013-09-23(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2013.09.016
bibo:pmid	24125830
has license	no-cc
sha1sum (hex)	59394b16db0ea888459926c7804d34a8e8f4ce6c
schema:url	https://doi.org/10.1016/j.jcv.2013.09.016
resource representing a document's title	Respiratory virus detection in nasopharyngeal aspirate versus bronchoalveolar lavage is dependent on virus type in children with chronic respiratory symptoms
has PubMed Central identifier	PMC7173340
has PubMed identifier	24125830
schema:publication	J Clin Virol
resource representing a document's body	covid:59394b16db0ea888459926c7804d34a8e8f4ce6c#body_text
is schema:about of	named entity 'aspirate' named entity 'chain reaction' named entity 'NPA' named entity 'evaluate' named entity 'respiratory' named entity 'Division' named entity 'Child Health' named entity 'SAMPLES' named entity '0.001' named entity 'DETERMINE' named entity 'PAIRED' named entity '398' named entity 'ASSOCIATIONS' named entity '95% CI' named entity 'specificity' named entity 'neutrophilic' named entity 'NPA' named entity '95% CI' named entity 'specificity' named entity 'respiratory' named entity 'yield' named entity 'PCR' named entity 'sensitivity' named entity 'neutrophilia' named entity 'virus' named entity 'NPA' named entity 'yield' named entity '95% CI' named entity 'HRV' named entity 'lower airway' named entity 'Viral' named entity 'Study design' named entity 'respiratory symptoms' named entity 'lower airway' named entity '95% CI' named entity '95% CI' named entity 'nasopharyngeal aspirate' named entity 'viruses' named entity 'viruses' named entity 'SPSS' named entity 'Enterobacteriaceae' named entity 'lower airway' named entity 'virus' named entity 'viruses' named entity 'tracheal' named entity 'atypical pneumonia' named entity 'bronchoalveolar lavage' named entity 'lower airway' named entity 'wheeze' named entity 'lower airway' named entity 'virus' named entity 'virus' named entity 'AstraZeneca' named entity 'normal saline' named entity 'HRV' named entity 'virus' named entity 'virus' named entity 'cigarette smoke' named entity 'shortness of breath' named entity 'virus' named entity 'lower airway' named entity 'HREC' named entity 'bronchoscopy' named entity 'bimodal distribution' named entity 'cohort study' named entity 'congenital' named entity 'PCR' named entity 'cough' named entity 'PCR techniques' named entity 'Bronchoscopic'

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