About: Middle East Respiratory Syndrome Coronavirus and the One Health concept

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About: Middle East Respiratory Syndrome Coronavirus and the One Health concept Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Middle East Respiratory Syndrome Coronavirus and the One Health concept
Creator	Gomaa Hemida, Maged
Source	Medline; PMC
abstract	Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is one of the major threats to the healthcare systems in some countries, especially in the Arabian Peninsula. MERS-CoV is considered an ideal example of the One Health concept. This is due to the animals, especially dromedary camels, play important roles in the transmission and sustainability of the virus, and the virus can be transmitted through aerosols of infected patients into the environment. However, there is some debate regarding the origin of MERS-CoV either from bats or other unknown reservoirs. The dromedary camel is the only identified animal reservoir to date. These animals play important roles in sustaining the virus in certain communities and may act as an amplifier of the virus by secreting it in their body fluids, especially in nasal and rectal discharges. MERS-CoV has been detected in the nasal and rectal secretions of infected camels, and MERS-CoV of this origin has full capacity to infect human airway epithelium in both in vitro and in vivo models. Other evidence confirms the direct transmission of MERS-CoV from camels to humans, though the role of camel meat and milk products has yet to be well studied. Human-to-human transmission is well documented through contact with an active infected patient or some silently infected persons. Furthermore, there are some significant risk factors of individuals in close contact with a positive MERS-CoV patient, including sleeping in the same patient room, removing patient waste (urine, stool, and sputum), and touching respiratory secretions from the index case. Outbreaks within family clusters have been reported, whereby some blood relative patients were infected through their wives in the same house were not infected. Some predisposing genetic factors favor MERS-CoV infection in some patients, which is worth investigating in the near future. The presence of other comorbidities may be another factor. Overall, there are many unknown/confirmed aspects of the virus/human/animal network. Here, the most recent advances in this context are discussed, and the possible reasons behind the emergence and sustainability of MERS-CoV in certain regions are presented. Identification of the exact mechanism of transmission of MERS-CoV from camels to humans and searching for new reservoir/s are of high priority. This will reduce the shedding of the virus into the environment, and thus the risk of human infection can be mitigated.
has issue date	2019-08-22(xsd:dateTime)
bibo:doi	10.7717/peerj.7556
bibo:pmid	31497405
has license	cc-by
sha1sum (hex)	58bb89f7722922bd9a47cd49e172c498d5cd73cf
schema:url	https://doi.org/10.7717/peerj.7556
resource representing a document's title	Middle East Respiratory Syndrome Coronavirus and the One Health concept
has PubMed Central identifier	PMC6708572
has PubMed identifier	31497405
schema:publication	PeerJ
resource representing a document's body	covid:58bb89f7722922bd9a47cd49e172c498d5cd73cf#body_text
is schema:about of	named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'patient' named entity 'rectal' named entity 'healthcare systems' named entity 'patient' named entity 'MERS-CoV' named entity 'animals' named entity 'clusters' named entity 'blood relative' named entity 'stool' named entity 'mitigated' named entity 'Arabian Peninsula' named entity 'touching' named entity 'concept' named entity 'THESE' named entity 'FACTOR' named entity 'DROMEDARY CAMEL' named entity 'CAPACITY' named entity 'INVESTIGATING' named entity 'HERE' named entity 'RESERVOIR' named entity 'RECTAL' named entity 'BLOOD RELATIVE' named entity 'CLUSTERS' named entity 'SIGNIFICANT' named entity 'PATIENT ROOM' named entity 'GENETIC FACTORS' named entity 'PRODUCTS' named entity 'PREDISPOSING' named entity 'IN VITRO' named entity 'SECRETIONS' named entity 'WIVES' named entity 'NASAL' named entity 'DISCHARGES' named entity 'AEROSOLS' named entity 'HEALTHCARE SYSTEMS' named entity 'HIGH PRIORITY' named entity 'DATE' named entity 'SECRETING' named entity 'INFECTED' named entity 'TRANSMISSION' named entity 'WORTH' named entity 'REGIONS' named entity 'TO INFECT' named entity 'INDEX CASE' named entity 'REMOVING' named entity 'MOST RECENT' named entity 'DROMEDARY' named entity 'THREATS' named entity 'MILK' named entity 'INFECTION' named entity 'REASONS' named entity 'COMORBIDITIES' named entity 'BATS' named entity 'REDUCE' named entity 'HOUSE' named entity 'IDEAL' named entity 'PRESENCE OF' named entity 'EMERGENCE' named entity 'NEW RESERVOIR' named entity 'PLAY' named entity 'IN VIVO' named entity 'HUMAN' named entity 'DETECTED' named entity 'ACT' named entity 'FAVOR' named entity 'OUTBREAKS' named entity 'IDENTIFICATION' named entity 'CONTACT WITH' named entity 'PATIENT' named entity 'PRESENTED' named entity 'CONCEPT' named entity 'MAJOR' named entity 'IMPORTANT' named entity 'ROLES' named entity 'EXACT' named entity 'INDIVIDUALS' named entity 'OVERALL' named entity 'EXAMPLE' named entity 'ARABIAN PENINSULA' named entity 'REPORTED'

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