About: Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

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About: Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth
Creator	Yin, Ping Navarro, Antonia Ono, Masanori Bulun, Serdar Coon, John Druschitz, Stacy Gottardi, Cara Moravek, Molly
Source	Elsevier; Medline; PMC
abstract	OBJECTIVE: Dysregulation of WNT signaling plays a central role in tumor cell growth and progression. Our goal was to assess the effect of three WNT/β-catenin pathway inhibitors, Inhibitor of β-Catenin And TCF4 (ICAT), niclosamide, and XAV939 on the proliferation of primary cultures of human uterine leiomyoma cells. DESIGN: Prospective study of human leiomyoma cells obtained from myomectomy or hysterectomy. SETTING: University research laboratory. PATIENT(S): Women (n=38) aged 27–53 years undergoing surgery. INTERVENTION(S): Adenoviral ICAT overexpression or treatment with varying concentrations of niclosamide or XAV939. MAIN OUTCOME MEASURE(S): Cell proliferation, cell death, WNT/β-catenin target gene expression or reporter gene regulation, β-catenin levels and cellular localization. RESULT(S): ICAT, niclosamide, or XAV939 inhibit WNT/β-catenin pathway activation and exert anti-proliferative effects in primary cultures of human leiomyoma cells. CONCLUSION(S): Three WNT/β-catenin pathway inhibitors specifically block human leiomyoma growth and proliferation, suggesting that the canonical WNT pathway may be a potential therapeutic target for the treatment of uterine leiomyoma. Our findings provide rationale for further preclinical and clinical evaluation of ICAT, niclosamide, and XAV939 as candidate anti-tumor agents for uterine leiomyoma.
has issue date	2014-05-01(xsd:dateTime)
bibo:doi	10.1016/j.fertnstert.2014.01.017
bibo:pmid	24534281
has license	green-oa
sha1sum (hex)	58b24c0d0846c4f4194996541f07540163433ec5
schema:url	https://doi.org/10.1016/j.fertnstert.2014.01.017
resource representing a document's title	Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth
has PubMed Central identifier	PMC4008647
has PubMed identifier	24534281
schema:publication	Fertility and Sterility
resource representing a document's body	covid:58b24c0d0846c4f4194996541f07540163433ec5#body_text
is schema:about of	named entity 'LEIOMYOMA CELL' named entity 'HUMAN' named entity 'UTERINE LEIOMYOMA' named entity 'ASSESS' named entity 'WNT' named entity 'XAV939' named entity 'SIGNALING' named entity 'INHIBITION' named entity 'CELL GROWTH' named entity 'HUMAN' named entity 'WNT' named entity 'PRIMARY CULTURES' named entity 'SIGNALING' named entity 'TCF4' named entity 'EFFECT' named entity 'PROGRESSION' named entity 'CENTRAL' named entity 'LEIOMYOMA CELLS' named entity 'OUR' named entity 'OBJECTIVE' named entity 'GOAL' named entity 'INHIBITOR' named entity 'ROLE' named entity 'PATHWAY INHIBITORS' named entity 'CATENIN' named entity 'TUMOR CELL' named entity 'NICLOSAMIDE' named entity 'PROLIFERATION' named entity 'PLAYS' named entity 'CELL GROWTH' named entity 'β-Catenin' named entity 'niclosamide' named entity 'WNT signaling' named entity 'leiomyoma' named entity 'epithelial cells' named entity 'cDNA' named entity 'MED12' named entity 'β-catenin' named entity 'leiomyoma' named entity 'Cell Proliferation' named entity 'cell growth' named entity 'niclosamide' named entity 'β-catenin' named entity 'tumorigenesis' named entity 'tissue culture' named entity 'nuclear localization' named entity 'fibroblast' named entity 'WNT signaling pathway' named entity 'leiomyoma' named entity 'uterus' named entity 'APC' named entity 'uterine bleeding' named entity 'Dallas' named entity 'antitumor' named entity 'nonionic' named entity 'TGFβ3' named entity 'leiomyoma' named entity 'Northwestern University' named entity 'down-regulated' named entity 'AXIN2' named entity 'adipogenesis' named entity 'mmol/L' named entity 'Wnt' named entity 'GST' named entity 'AXIN2' named entity 'Infection' named entity 'conjugated' named entity 'University of Tokyo' named entity 'cytosolic' named entity 'βcatenin' named entity 'β-Catenin' named entity 'NKD1' named entity 'β-catenin' named entity 'smooth muscle cell'

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