About: Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction
Creator	Chen, Jaw-Chyun Ho, Tin-Yun Hsiang, Chien-Yun Li, Chia-Cheng Wu, Shih-Lu
Source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV). SARS-CoV spike (S) protein, a type I membrane-bound protein, is essential for the viral attachment to the host cell receptor angiotensin-converting enzyme 2 (ACE2). By screening 312 controlled Chinese medicinal herbs supervised by Committee on Chinese Medicine and Pharmacy at Taiwan, we identified that three widely used Chinese medicinal herbs of the family Polygonaceae inhibited the interaction of SARS-CoV S protein and ACE2. The IC50 values for Radix et Rhizoma Rhei (the root tubers of Rheum officinale Baill.), Radix Polygoni multiflori (the root tubers of Polygonum multiflorum Thunb.), and Caulis Polygoni multiflori (the vines of P. multiflorum Thunb.) ranged from 1 to 10μg/ml. Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner. It also inhibited the infectivity of S protein-pseudotyped retrovirus to Vero E6 cells. These findings suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.
has issue date	2007-05-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2006.04.014
bibo:pmid	16730806
has license	els-covid
sha1sum (hex)	587cd9817ce5be8ee1892b5d0fd269612f1c3c0c
schema:url	https://doi.org/10.1016/j.antiviral.2006.04.014
resource representing a document's title	Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction
has PubMed Central identifier	PMC7114332
has PubMed identifier	16730806
schema:publication	Antiviral Research
resource representing a document's body	covid:587cd9817ce5be8ee1892b5d0fd269612f1c3c0c#body_text
is schema:about of	named entity 'SPIKE PROTEIN' named entity 'essential' named entity 'type I' named entity 'anthraquinone' named entity 'cells' named entity 'root' named entity 'caused' named entity 'root' named entity 'receptor' named entity 'ACE2' named entity 'interaction' named entity 'GENUS' named entity 'TUBERS' named entity 'TREATMENT' named entity 'SPIKE' named entity 'THERAPEUTIC AGENT' named entity 'BLOCKED' named entity 'S PROTEIN' named entity 'CONSIDERED' named entity '312' named entity 'POLYGONUM MULTIFLORUM' named entity 'CAULIS' named entity 'CONTROLLED' named entity 'POLYGONUM' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'TYPE I' named entity 'INTERACTION' named entity 'ROOT' named entity 'RHIZOMA' named entity 'MEDICINAL HERBS' named entity 'USED' named entity 'ACE2' named entity 'SARS CORONAVIRUS' named entity 'INTERACTION' named entity 'EMODIN' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'BLOCKS' named entity 'RHEUM' named entity 'SCREENING' named entity 'MAY BE' named entity 'COMMITTEE' named entity 'CAUSED BY' named entity 'RETROVIRUS' named entity 'EMODIN' named entity 'PROTEIN ' named entity 'FINDINGS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'VIRAL ATTACHMENT' named entity 'DOSE-DEPENDENT' named entity 'CHINESE MEDICINE' named entity 'RECEPTOR' named entity 'VALUES' named entity 'PHARMACY' named entity 'POLYGONACEAE' named entity 'MEMBRANE' named entity 'CELLS' named entity 'SARS' named entity 'THESE' named entity 'VINES' named entity 'RHEUM OFFICINALE BAILL.' named entity 'TAIWAN' named entity '28S' named entity 'NOVEL CORONAVIRUS' named entity 'EMERGING INFECTIOUS DISEASE' named entity 'INFECTIVITY' named entity 'FAMILY' named entity 'DERIVED' named entity 'HOST CELL' named entity 'SARS-COV' named entity 'BOUND' named entity 'INHIBITED' named entity 'PROTEIN' named entity 'ESSENTIAL' named entity 'CHINESE' named entity 'PROTEIN ' named entity 'ANTHRAQUINONE COMPOUND' named entity 'IDENTIFIED'

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