About: Burden of disease due to human coronavirus NL63 infections and periodicity of infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Burden of disease due to human coronavirus NL63 infections and periodicity of infection
Creator	Vabret, Astrid Berkhout, Ben Dijkman, Ronald Forster, Johannes Ihorst, Gabriele Sure, Klaus Uberla, Klaus De Vries, Michel Van Der Hoek, Lia
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: The disease burden caused by recently identified respiratory viruses like HCoV-NL63 is unknown. OBJECTIVES: We determined the burden of disease due to HCoV-NL63 infections using the population-based PRI.DE cohort of children under the age of 3 with lower respiratory tract infections (LRTIs). STUDY DESIGN: In total 1756 respiratory samples, from hospitalized children or children who visited the outpatient clinic, were tested for HCoV-NL63. Sampling covered a period of 2 years and the frequency of infection in different years was compared to other Western European studies that tested for this virus in 2 or more consecutive years. RESULTS: Sixty-nine samples were HCoV-NL63 positive, 35 were with high loads, and of these 25 were single HCoV-NL63 infections. Based on the number of children with high HCoV-NL63 infection and no additional infection, the overall annual incidence in outpatients was 7 per 1000 children per year (95% confidence interval (CI) 3–13 per 1000 children per year), which can be extrapolated to an absolute number of 16,929 visits to the physician due to an HCoV-NL63 infection in Germany per year. The estimated hospitalization rate is 22 per 100,000 children (95% CI: 7–49 per 100,000 children per year). This number reflects 522 HCoV-NL63 children in Germany per year. A large year-to-year difference in HCoV-NL63 infection frequency was observed. Combining these data with those of other studies in Western Europe revealed that HCoV-NL63 infections follow a 2-year inter-epidemic period with peaks of infection in the winters of 2000/2001, 2002/2003 and 2004/2005 (p < 0.0001). CONCLUSIONS: HCoV-NL63 infection in children below 3 years of age often requires a visit to the physician in an outpatient clinic, especially during peak-years, but hospitalizations are relatively infrequent.
has issue date	2010-03-29(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2010.02.023
bibo:pmid	20347384
has license	no-cc
sha1sum (hex)	5812874ab504cb809830a46d808d2cb81f56f73b
schema:url	https://doi.org/10.1016/j.jcv.2010.02.023
resource representing a document's title	Burden of disease due to human coronavirus NL63 infections and periodicity of infection
has PubMed Central identifier	PMC7108429
has PubMed identifier	20347384
schema:publication	J Clin Virol
resource representing a document's body	covid:5812874ab504cb809830a46d808d2cb81f56f73b#body_text
is schema:about of	named entity 'large' named entity 'high' named entity 'disease' named entity 'COVERED' named entity 'CONSECUTIVE' named entity 'ABSOLUTE NUMBER' named entity 'INFECTION' named entity 'CONCLUSIONS' named entity 'GERMANY' named entity 'NUMBER OF CHILDREN' named entity 'WINTERS' named entity 'PRI' named entity 'WESTERN EUROPE' named entity 'OUTPATIENT CLINIC' named entity 'DIFFERENCE' named entity 'PEAKS' named entity 'CAUSED BY' named entity 'HCOV-NL63' named entity 'YEAR' named entity 'LOWER RESPIRATORY TRACT INFECTIONS' named entity 'CONFIDENCE INTERVAL' covid:arg/5812874ab504cb809830a46d808d2cb81f56f73b named entity 'BUT' named entity 'INTER-' named entity 'DUE TO' named entity 'OBSERVED' named entity 'POSITIVE' named entity 'INFECTION' named entity 'INFECTIONS' named entity 'DUE TO' named entity 'HUMAN CORONAVIRUS NL63' named entity 'BURDEN OF DISEASE' named entity 'NUMBER' named entity 'REVEALED' named entity 'SAMPLING' named entity 'FOLLOW' named entity 'BACKGROUND' named entity 'VIRUS' named entity 'PEAK' named entity 'FREQUENCY' named entity 'COMBINING' named entity 'HOSPITALIZATIONS' named entity 'RECENTLY' named entity 'CHILDREN' named entity 'PERIOD' named entity 'VISITS' named entity 'YEARS' named entity 'THESE' named entity 'HOSPITALIZED CHILDREN' named entity 'IDENTIFIED' named entity '2 OR MORE' named entity 'PERIODICITY' named entity 'VISIT' named entity 'BURDEN' named entity 'HOSPITALIZATION RATE' named entity 'COHORT' named entity 'COMPARED' named entity 'ESTIMATED' named entity 'RESULTS' named entity 'RESPIRATORY VIRUSES' named entity 'SIXTY-NINE' named entity 'TOTAL' named entity 'STUDY DESIGN' named entity 'SAMPLES' named entity 'ANNUAL INCIDENCE' named entity '28P' named entity 'DETERMINED' named entity 'TESTED FOR' named entity '100%' named entity 'DIFFERENT' named entity 'INFECTIONS' named entity 'DISEASE' named entity 'AGE'

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