About: Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold

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About: Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold
Creator	Chen, Lijuan Chen, Zhuo Li, Qin Ruan, Xianghui Wang, Xiaobin Xue, Wei Zhang, Juping Zhong, Xinmin
Source	Medline; PMC
abstract	BACKGROUND: Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin analogues with potent activities, a series of novel myricetin derivatives containing 1,3,4-thiadiazole moiety were synthesized, and their antibacterial and antiviral activities were evaluated. RESULT: Bioassay results indicated that some target compounds exhibited potential antibacterial and antiviral activities. Among them, compounds 2, 3a, 3b, 3d, 3f, 3i, 3m and 3p exhibited excellent antibacterial activities against Xanthomonas oryzae pv. Oryzae (Xoo), with EC(50) values of 42.7, 38.6, 20.8, 12.9, 22.7, 27.3, 18.3 and 29.4 μg/mL, respectively, which were better than that of thiadiazole-copper (94.9 μg/mL). Compounds 3b, 3d, 3e, 3f, 3i and 3o showed good antibacterial activities against Ralstonia solanacearum (Rs), with EC(50) values of 37.9, 72.6, 43.6, 59.6, 60.6 and 39.6 μg/mL, respectively, which were superior to that of thiadiazole-copper (131.7 μg/mL). In addition, compounds 3d, 3f, 3i and 3m showed better curative activities against tobacco mosaic virus (TMV), with EC(50) values of 152.8, 99.7, 127.1, and 167.3 μg/mL, respectively, which were better than that of ningnanmycin (211.1 μg/mL). CONCLUSIONS: A series of myricetin derivatives containing 1,3,4-thiadiazole scaffold were synthesized, and their antibacterial activities against Xoo and Rs and their antiviral activity against TMV were evaluated. Bioassays indicated that some target compounds exhibited potential antibacterial and antiviral activities. These results indicated this kind of myricetin analogues could be further studied as potential alternative templates in the search for novel antibacterial and antiviral agents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13065-017-0336-7) contains supplementary material, which is available to authorized users.
has issue date	2017-10-17(xsd:dateTime)
bibo:doi	10.1186/s13065-017-0336-7
bibo:pmid	29086886
has license	cc-by
sha1sum (hex)	57d7804297acdd855f4f2e2a6903cf6ca04d323e
schema:url	https://doi.org/10.1186/s13065-017-0336-7
resource representing a document's title	Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold
has PubMed Central identifier	PMC5645266
has PubMed identifier	29086886
schema:publication	Chem Cent J
resource representing a document's body	covid:57d7804297acdd855f4f2e2a6903cf6ca04d323e#body_text
is schema:about of	named entity 'myricetin' named entity 'Synthesis' covid:arg/57d7804297acdd855f4f2e2a6903cf6ca04d323e named entity 'Background' named entity 'moiety' named entity 'VECTOR' named entity 'antiviral activity' named entity 'room temperature' named entity 'reaction mixture' named entity 'thiadiazole' named entity 'moiety' named entity 'thiadiazole' named entity 'thiadiazole' named entity 'thiadiazole' named entity 'myricetin' named entity 'TMV' named entity 'TMV' named entity 'antibacterial' named entity 'thiadiazole' named entity 'infrared spectrum' named entity 'heterocycle' named entity 'Beijing' named entity 'heterocycles' named entity 'Shanghai' named entity 'NMR spectra' named entity 'antifungal' named entity 'environmentally friendly' named entity 'biological activities' named entity 'thiazol' named entity 'moiety' named entity 'antibacterial activity' named entity 'viruses' named entity 'copper' named entity 'Xoo' named entity 'thiadiazoles' named entity 'inhibitory activity' named entity 'HRMS' named entity 'DMSO' named entity 'antibacterial' named entity 'Chemistry' named entity 'pesticides' named entity 'TMV' named entity 'myricetin' named entity 'C=O' named entity 'thiadiazole' named entity 'China' named entity 'copper' named entity 'thiadiazole' named entity 'anxiolytic' named entity 'agrochemicals' named entity 'JEOL' named entity 'internal standard' named entity 'antibacterial' named entity 'mmol' named entity 'TMV' named entity 'Toona sinensis' named entity 'nuclear magnetic resonance (NMR) spectroscopy' named entity 'antinociceptive' named entity 'leaf blight' named entity 'antiviral activity' named entity 'Xoo' named entity 'Xoo' named entity 'Xoo' named entity 'Xanthomonas oryzae pv. oryzae' named entity 'biological activities' named entity 'thiazol' named entity 'heterocycles' named entity 'thiadiazole' named entity 'antibacterial activity' named entity '1, 2' named entity 'melting points' named entity 'antibacterial activity' named entity 'Xoo' named entity 'TMV'

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