About: Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013

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About: Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013–2015 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013–2015
Creator	Ren, Lili Tan, Wenjie Zhang, Qiwei Lu, Roujian Zhao, Yanjie Shen, Jun Liu, Gaoshan Wu, Bingjie Mei, Ya-Fang
Source	Medline; PMC
abstract	Human rhinovirus (HRV), and particularly HRV-C, is increasingly recognized as a cause of severe acute respiratory infections (SARIs). However, little is known about the genotypic diversity and epidemiology of HRV among children with SARI. Thus, we investigated the genotypic diversity and epidemiology of HRV in children with SARI in China over a 2-year period. In total 1,003, nasopharyngeal aspirates were collected from children hospitalized with SARI in Shanghai from 2013 to 2015. HRV was screened for by a PCR method targeting the viral 5′ UTR and was genotyped by sequencing of the VP4–VP2 region of the HRV genome. We also screened for 15 other common respiratory viruses to assess the prevalence of co-infection with HRV. The patient demographic and clinical data were reviewed. HRV was detected in 280 (27.9%) of the 1,003 specimens: HRV-A in 140 (14.0%), HRV-B in 21 (2.1%), HRV-C in 56 (5.6%), and HRV-untyped in 63 (6.3%). A phylogenetic analysis identified 77 genotypes (43 HRV-A, 10 HRV-B, and 24 HRV-C), among which A78, A12, A89, B70, C2, C6, and C24 predominated. HRV-A was detected mainly in winter 2013 and autumn 2014, while HRV-C detection peaked in autumn 2013 and 2014. The detection frequency of HRV-A was highest in patients <5 years old. Most HRV co-infections involved adenovirus, human bocavirus, and/or human respiratory syncytial virus. In conclusion, HRV-A and -C predominate in children with SARI in Shanghai. Among the 77 genotypes detected, A78, A12, A89, B70, C2, C6, and C24 were the most frequent. The HRV species responsible for SARIs differs according to season and age.
has issue date	2018-08-07(xsd:dateTime)
bibo:doi	10.3389/fmicb.2018.01836
bibo:pmid	30131797
has license	cc-by
sha1sum (hex)	57d6bf2cc1fc387a33ba3ff4343e0bbd7a12dfaf
schema:url	https://doi.org/10.3389/fmicb.2018.01836
resource representing a document's title	Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013–2015
has PubMed Central identifier	PMC6090050
has PubMed identifier	30131797
schema:publication	Front Microbiol
resource representing a document's body	covid:57d6bf2cc1fc387a33ba3ff4343e0bbd7a12dfaf#body_text
is schema:about of	named entity 'GENOTYPIC' named entity 'genotypes' named entity 'respiratory' named entity 'data' named entity 'Human' named entity 'With' named entity '2015' named entity 'RESPIRATORY VIRUSES' named entity 'SPECIMENS' named entity 'PATIENT DEMOGRAPHIC' named entity 'CHINA' named entity 'INVESTIGATED' named entity 'AUTUMN' named entity 'KNOWN' named entity 'A89' named entity 'CAUSE' named entity 'GENOME' named entity 'B70' named entity 'CLINICAL DATA' named entity 'SEVERE' named entity 'DETECTION' named entity 'HUMAN BOCAVIRUS' named entity 'SEQUENCING' named entity 'VIRAL' named entity 'TARGETING' named entity '282' named entity 'C24' named entity 'CONCLUSION' named entity 'CHILDREN HOSPITALIZED' named entity 'VP4' named entity 'ACUTE RESPIRATORY INFECTIONS' named entity '2015' named entity 'GENOTYPES' named entity 'CHILDREN' named entity 'NASOPHARYNGEAL' named entity 'COLLECTED' named entity 'WINTER' named entity 'RESPONSIBLE' named entity 'HIGHEST' named entity 'PERIOD' named entity 'TOTAL' named entity 'ADENOVIRUS' named entity 'PCR METHOD' named entity 'ACCORDING' named entity 'REVIEWED' named entity 'SARIS' named entity 'SEASON' named entity 'LITTLE' named entity 'PEAKED' named entity 'AGE' named entity 'PATIENTS' named entity 'DIVERSITY' named entity 'DIVERSITY' named entity 'SEVERE' named entity 'EPIDEMIOLOGY' named entity 'ACUTE RESPIRATORY TRACT INFECTION' named entity 'CHILDREN' named entity 'HRV' named entity 'GENOTYPIC' named entity 'YEAR' named entity 'HRV-A' named entity 'EPIDEMIOLOGY' named entity 'YEARS' named entity '140' named entity 'UTR' named entity 'OLD' named entity 'A12' named entity 'SARI' named entity 'PREDOMINATED' named entity 'ASSESS' named entity 'SPECIES' named entity 'VP2' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS'

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