About: Cross-reactivity of neutralizing antibody and its correlation with circulating T follicular cells in recovered COVID-19 individuals

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cross-reactivity of neutralizing antibody and its correlation with circulating T follicular cells in recovered COVID-19 individuals Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cross-reactivity of neutralizing antibody and its correlation with circulating T follicular cells in recovered COVID-19 individuals
Creator	Zhang, Jian Li, Yi-Ping Wu, Qian Huang, Weijin Wang, Youchun Niu, Ling Liu, Wenpei Qu, Xiaowang Wu, Tiantian Huang, Renbin Peng, Danhong Wu, Jiajing Xie, Ting Luo, Dixian Liu, Ziyan Bai, Tingting Chen, Haifu Deng, Yunfan Guo, Wangyuan He, Shuangyan Hu, Yabin Huang, Mincheng Jin, Kun Lei, Dongzhu Li, Guicheng Li, Weilang Lin, Yingbiao Liu, Jianghua Lu, Zhongyi Luo, Qingting Wang, Qijie Wu, Zhijian Xie, Xiangping Zeng, Ting
Source	MedRxiv
abstract	Seroconversion appeared early after COVID-19 onset, and convalescent sera therapy benefit some critical patients. However, neutralizing antibody (nAb) in convalescents is largely unknown. We found that 97.01% (65/67) of COVID-19 convalescents maintained IgG antibodies with high binding and avidity to SARS-CoV-2 spike subunits S1 and S2, and 95.52% (64/67) had neutralization activity against SARS-CoV-2 pesudovirus, one month after discharge (median ID50, 2.75; IQR, 2.34-3.08). Some sera exhibited cross-neutralization against SARS-CoV (76.12%), MERS-CoV (17.91%), or both (10.45%). Interestingly, individuals recovered from severe disease (severe group) had nAbs with binding and neutralization titers higher than non-severe group. Severe group appeared a rapid increase of lymphocytes and a high proportion of circulating CXCR3+ Tfh cells. Interestingly, the later were spike-specific and positively correlated with SARS-CoV-2 nAb titers. All subjects had no autoimmunity. Our findings provide novel insights into nAb responses in COVID-19 convalescents and facilitate treatment and vaccine development for SARS-CoV-2 infection.
has issue date	2020-06-14(xsd:dateTime)
bibo:doi	10.1101/2020.06.12.20129460
has license	medrxiv
sha1sum (hex)	57be2b8cc4b861cd2dbda6bb731990563f3932d5
schema:url	https://doi.org/10.1101/2020.06.12.20129460
resource representing a document's title	Cross-reactivity of neutralizing antibody and its correlation with circulating T follicular cells in recovered COVID-19 individuals
resource representing a document's body	covid:57be2b8cc4b861cd2dbda6bb731990563f3932d5#body_text
is schema:about of	named entity 'All' named entity 'high' named entity 'development' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'individuals' named entity 'recovered' covid:arg/57be2b8cc4b861cd2dbda6bb731990563f3932d5 named entity 'MERS-CoV' named entity 'responses' named entity 'nAb' named entity 'maintained' named entity 'patients' named entity 'severe' named entity 'Cross-reactivity' named entity 'circulating' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'infection' named entity 'positively correlated' named entity 'lymphocytes' named entity 'SARS-CoV' named entity 'MERS-CoV' named entity 'autoimmunity' named entity 'COVID-19' named entity 'Seroconversion' named entity 'Cross-reactivity' named entity 'SARS-CoV-2' named entity 'peer review' named entity 'Mann-Whitney U test' named entity 'preprint' named entity 'pseudovirus' named entity 'avidity' named entity 'serum' named entity 'SARS-CoV-2' named entity 'viral shedding' named entity 'negative control' named entity 'preprint' named entity 'antibodies' named entity 'probability' named entity 'San Diego' named entity 'Rank Correlation' named entity 'PBS' named entity 'preprint' named entity 'antibody' named entity 'critical role' named entity 'CXCR3' named entity 'antibody' named entity 'PBMCs' named entity 'SARS-CoV-2' named entity 'preprint' named entity 'antibodies'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software