About: Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies
Creator	Feuer, Ralph Burrer, Renaud Iglesias, Antonio Wolfe, Tom Buchmeier, Michael Ting, Joey Von Herrath, Matthias
Source	Elsevier; Medline; PMC
abstract	We examine here the outcome of viral encephalomyelitis [mouse hepatitis virus (MHV) A59, Theiler’s encephalomyelitis virus, and Coxsackievirus B3] in mice with autoantibodies to a central nervous system (CNS)-specific antigen, myelin oligodendrocyte glycoprotein, that usually develop no clinical disease. Morbidity and mortality of the acute viral CNS disease was augmented by the presence of the autoantibodies in all three viral infections. Transfer of serum containing the autoantibodies at the time of infection with MHV was sufficient to reproduce the exacerbated disease. The presence of the autoantibodies was found to result in increased infiltration of mononuclear cells into the brain. Early demyelination was severely augmented in brains and spinal cords of MHV-infected mice with CNS-specific autoantibodies. The antibody-mediated exacerbation was shown to be independent of the complement system but to require expression of Fc receptors, because it was observed in C′-3-deficient but not in Fc receptor-deficient mice. Our study illustrates the possibility that infections can lead to much more profound immunopathology in the presence of an otherwise latent autoimmune condition.
has issue date	2007-02-01(xsd:dateTime)
bibo:doi	10.2353/ajpath.2007.060893
bibo:pmid	17255324
has license	green-oa
sha1sum (hex)	57bcd251e2d4f611eddf330ca913ba880dd94576
schema:url	https://doi.org/10.2353/ajpath.2007.060893
resource representing a document's title	Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies
has PubMed Central identifier	PMC1851853
has PubMed identifier	17255324
schema:publication	The American Journal of Pathology
resource representing a document's body	covid:57bcd251e2d4f611eddf330ca913ba880dd94576#body_text
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