About: In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity

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About: In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity
Creator	Brabb, Thea Duke, Blythe Goverman, Joan Ordonez, Nadia Schnabel, Bryan Von Dassow, Peter
Source	PMC
abstract	Multiple sclerosis (MS) is believed to be an autoimmune disease in which autoreactive T cells infiltrate the central nervous system (CNS). Animal models of MS have shown that CNS-specific T cells are present in the peripheral T cell repertoire of healthy mice and cause autoimmune disease only when they are activated by immunization. T cell entry into the CNS is thought to require some form of peripheral activation because the blood–brain barrier prohibits trafficking of this tissue by naive cells. We report here that naive T cells can traffic to the CNS without prior activation. Comparable numbers of T cells are found in the CNS of both healthy recombinase activating gene (Rag)(−/)− T cell receptor (TCR) transgenic mice and nontransgenic mice even when the transgenic TCR is specific for a CNS antigen. Transgenic T cells isolated from the CNS that are specific for non-CNS antigens are phenotypically naive and proliferate robustly to antigenic stimulation in vitro. Strikingly, transgenic T cells isolated from the CNS that are specific for myelin basic protein (MBP) are also primarily phenotypically naive but are unresponsive to antigenic stimulation in vitro. Mononuclear cells from the CNS of MBP TCR transgenic but not nontransgenic mice can suppress the response of peripheral MBP-specific T cells in vitro. These results indicate that naive MBP-specific T cells can traffic to the CNS but do not trigger autoimmunity because they undergo tolerance induction in situ.
has issue date	2000-09-18(xsd:dateTime)
bibo:pmid	10993917
has license	cc-by-nc-sa
sha1sum (hex)	57b32baae9c8cfd1be336a341fe0df2a55ad57bb
resource representing a document's title	In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity
has PubMed Central identifier	PMC2193284
has PubMed identifier	10993917
schema:publication	J Exp Med
resource representing a document's body	covid:57b32baae9c8cfd1be336a341fe0df2a55ad57bb#body_text
is schema:about of	named entity 'TRAFFICKING' named entity 'UNRESPONSIVE TO' named entity 'ACTIVATED' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'TCR' named entity 'IMMUNIZATION' named entity 'T CELL' named entity 'ISOLATED' named entity 'HERE' named entity 'AUTOIMMUNE DISEASE' named entity 'NON-' named entity 'TRANSGENIC' named entity 'BLOOD-BRAIN BARRIER' named entity 'ANIMAL MODELS ' named entity 'ANTIGEN' named entity 'TRAFFIC' named entity 'RESPONSE' named entity 'T cells' named entity 'CNS' named entity 'phenotypically' named entity 'trafficking' named entity 'isolated' named entity 'Animal models' named entity 'IN SITU' named entity 'RESULTS' named entity 'REPERTOIRE' named entity 'GENE' named entity 'REPORT' named entity 'ENTRY' named entity 'TRIGGER' named entity 'MULTIPLE SCLEROSIS' named entity 'SUPPRESS' named entity 'CELLS' named entity 'MICE' named entity 'CAUSE' named entity 'THOUGHT' named entity 'DO NOT' named entity 'PREVENTING' named entity 'MECHANISM' named entity 'AUTOIMMUNITY' named entity 'TOLERANCE' named entity 'ANTIGENS' named entity 'PRIOR' named entity 'STIMULATION' named entity 'NUMBERS' named entity 'TRANSGENIC MICE' named entity 'IN VITRO' named entity 'RECOMBINASE' named entity 'IN SITU' named entity 'BUT' named entity 'PRESENT' named entity 'TOLERANCE INDUCTION' named entity 'SPECIFIC' named entity 'T CELL RECEPTOR' named entity 'AUTOIMMUNITY' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'MYELIN BASIC PROTEIN' named entity 'MBP' named entity 'PERIPHERAL' named entity 'T CELLS' named entity 'MONONUCLEAR CELLS' named entity 'THESE' named entity 'CNS' named entity 'PROTEIN ' named entity 'ACTIVATING' named entity 'NAIVE T CELLS' named entity 'FORM' named entity 'HEALTHY' named entity 'HAVE' named entity 'TISSUE' named entity 'INFILTRATE' named entity 'ACTIVATION' covid:arg/57b32baae9c8cfd1be336a341fe0df2a55ad57bb named entity 'receptor' named entity 'naive' named entity 'T cells' named entity 'trigger' named entity 'mice'

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