About: Angiotensin-Converting Enzyme 2 as a Therapeutic Target for Heart Failure

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Angiotensin-Converting Enzyme 2 as a Therapeutic Target for Heart Failure
Creator	Wilson Tang, W Chamsi-Pasha, Mohammed Zhili, &
Source	PMC
abstract	The renin-angiotensin system (RAS) plays a major role in the pathophysiology of cardiovascular disorders. Angiotensin II (Ang-II), the final product of this pathway, is known for its vasoconstrictive and proliferative effects. Angiotensin-converting enzyme 2 (ACE2), a newly discovered homolog of ACE, plays a key role as the central negative regulator of the RAS. It diverts the generation of vasoactive Ang-II into the vasodilatory and growth inhibiting peptide angiotensin(1–7) [Ang(1–7)], thereby providing counter-regulatory responses to neurohormonal activation. There is substantial experimental evidence evaluating the role of ACE2/Ang(1–7) in hypertension, heart failure, and atherosclerosis. In this review, we aim to focus on the conceptual facts of the ACE2-Ang(1–7) axis with regards to clinical implications and therapeutic targets in cardiovascular disorders, with emphasis on the potential therapeutic role in cardiovascular diseases.
has issue date	2013-11-30(xsd:dateTime)
bibo:doi	10.1007/s11897-013-0178-0
bibo:pmid	24293035
has license	no-cc
sha1sum (hex)	57a767e47fb0123d877b18381e88181b2f24a807
schema:url	https://doi.org/10.1007/s11897-013-0178-0
resource representing a document's title	Angiotensin-Converting Enzyme 2 as a Therapeutic Target for Heart Failure
has PubMed Central identifier	PMC3944399
has PubMed identifier	24293035
schema:publication	Curr Heart Fail Rep
resource representing a document's body	covid:57a767e47fb0123d877b18381e88181b2f24a807#body_text
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