About: Evaluation of recombinant fowlpox virus expressing infectious bronchitis virus S1 gene and chicken interferon-γ gene for immune protection against heterologous strains

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About: Evaluation of recombinant fowlpox virus expressing infectious bronchitis virus S1 gene and chicken interferon-γ gene for immune protection against heterologous strains Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of recombinant fowlpox virus expressing infectious bronchitis virus S1 gene and chicken interferon-γ gene for immune protection against heterologous strains
Creator	Zhao, Yan Wang, Mei Jing, Zhang Wang, Yun-Feng Cui, Hong-Yu Gao, Hong-Bo Shi, Xing-Ming Tong, Gang-Zhi
Source	Elsevier; Medline; PMC
abstract	Abstract A recombinant fowlpox virus (rFPV-IFNγS1) that co-expressed the infectious bronchitis virus (IBV) S1 gene and the chicken interferon-γ gene has been constructed. To evaluate the efficacy of the recombinant fowlpox virus vaccine against heterotypic IBV strains, 60 4-week-old Specific-Pathogen-Free (SPF) chickens were inoculated with this vaccine and 3 weeks post inoculation challenged with the homotypic IBV strain LX4 and the heterotypic IBV strains LHB, LHLJ04XI, LTJ95I and LSC99I. Antibodies against IBV were detected in vaccinated chickens 1-week post inoculation. The number of CD4+ and CD8+ T-lymphocytes in the peripheral blood increased rapidly in the vaccinated groups challenged with strains LX4, LHB and LHLJ04XI. There were significant differences in the number of CD4+ and CD8+ T-lymphocytes between the vaccinated groups challenged with strains LTJ95I and LSC99I and all the control groups. The morbidity was below 30% in vaccinated groups challenge with strains LX4, LHB and LHLJ04XI, but was 40% greater than that in the other groups. In addition, the lesions and the amount of virus shedding were less severe in the vaccinated groups challenged by strains LX4, LHB and LHLJ04XI when compared with the other groups, but there was no significant difference in the average body weight of the chickens in all groups (all p >0.05). These results indicate that the rFPV-IFNγS1 protected chickens against challenge with homotypic IBV strain LX4 and heterotypic strains LHLJ04XI and LHB.
has issue date	2011-02-11(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2010.12.102
bibo:pmid	21216313
has license	els-covid
sha1sum (hex)	5795ad5d53c8a5d68451ac2e7e81ead8e95cf2a4
schema:url	https://doi.org/10.1016/j.vaccine.2010.12.102
resource representing a document's title	Evaluation of recombinant fowlpox virus expressing infectious bronchitis virus S1 gene and chicken interferon-γ gene for immune protection against heterologous strains
has PubMed Central identifier	PMC7172633
has PubMed identifier	21216313
schema:publication	Vaccine
resource representing a document's body	covid:5795ad5d53c8a5d68451ac2e7e81ead8e95cf2a4#body_text
is schema:about of	named entity 'vaccinated' named entity 'strains' named entity 'IBV' named entity 'These' named entity 'gene' named entity 'greater' named entity 'chicken' named entity 'chicken' named entity 'vaccine' named entity 'fowlpox virus' named entity 'number' named entity 'groups' named entity 'CD8' named entity 'vaccinated' named entity 'strains' named entity 'recombinant' named entity 'recombinant' named entity 'IBV' named entity 'infectious bronchitis virus' named entity 'CD8 +' named entity 'chicken' named entity 'recombinant' named entity 'Specific-Pathogen-Free' named entity 'CD8 +' named entity 'fowlpox virus' named entity 'fowlpox virus' named entity 'interferon' named entity 'chicken' named entity 'peripheral blood' named entity 'stromal cell' named entity 'CD8 +' named entity 'immunoprotection' named entity 'allantoic' named entity 'IBV' named entity 'RT-PCR' named entity 'chicken' named entity 'randomly selected' named entity 'infectious bronchitis virus' named entity 'coronaviruses' named entity 'virus' named entity 'IBV' named entity 'Antibody' named entity 'chicken' named entity 'attenuated vaccines' named entity 'virus' named entity 'molecular epidemiology' named entity 'precipitation' named entity 'infectious bronchitis virus' named entity 'chicken' named entity 'IBV' named entity 'kidney' named entity 'vaccination' named entity 'IDEXX' named entity 'vaccination' named entity 'infectious bronchitis virus' named entity 'embryos' named entity 'pathology' named entity 'infectious bronchitis virus' named entity 'inoculate' named entity 'IBV' named entity 'chicken' named entity 'Throat swab' named entity 'IBV' named entity 'IBV' named entity 'CD4 +' named entity 'vacuolation' named entity 'CD8' named entity 'IBV' named entity 'infectious bronchitis virus' named entity 'lung' named entity 'immune regulation' named entity 'gene' named entity 'virus' named entity 'IBV'

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