About: Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature

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About: Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature
Creator	Montemurro, Nicola Carlo, Di Ceravolo, Roberto Perrini, Paolo Petrella, Giandomenico Siciliano, Gabriele Tiziano, Davide
Source	Medline; PMC
abstract	OBJECT: The novel severe acute respiratory syndrome (SARS)-CoV-2 outbreak has been declared a pandemic in March, 2020. An increasing body of evidence suggests that patients with the coronavirus disease (COVID-19) might have a heterogeneous spectrum of neurological symptoms METHODS: A systematic search of two databases was performed for studies published up to May 29th, 2020. PRISMA guidelines were followed. RESULTS: We included 19 studies evaluating 12,157 patients with laboratory-confirmed COVID-19 infections. The median age of patients was 50.3 (IQR 11.9), and the rate of male patients was 50.6% (95% CI 49.2–51.6%). The most common reported comorbidities were hypertension and diabetes (31.1%, 95% CI 30–32.3% and 13.5%, 95% CI 12.3–14.8%, respectively). Headache was reported in 7.5% of patients (95% CI 6.6–8.4%), and dizziness in 6.1% (95% CI 5.1–7.1%). Hypo/anosmia, and gustatory dysfunction were reported in 46.8 and 52.3%, of patients, respectively. Symptoms related to muscular injury ranged between 15 and 30%. Three studies reported radiological confirmed acute cerebrovascular disease in 2% of patients (95% CI 1.6–2.4%). CONCLUSIONS: These data support accumulating evidence that a significant proportion of patients with COVID-19 infection develop neurological manifestations, especially olfactory, and gustatory dysfunction. The pathophysiology of this association is under investigation and warrants additional studies, Physicians should be aware of this possible association because during the epidemic period of COVID-19, early recognition of neurologic manifestations otherwise not explained would raise the suspect of acute respiratory syndrome coronavirus 2 infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00415-020-09978-y) contains supplementary material, which is available to authorized users.
has issue date	2020-08-01(xsd:dateTime)
bibo:doi	10.1007/s00415-020-09978-y
bibo:pmid	32740766
has license	no-cc
sha1sum (hex)	5773cb993bbabdc1c5db06f775e006c723bf368e
schema:url	https://doi.org/10.1007/s00415-020-09978-y
resource representing a document's title	Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature
has PubMed Central identifier	PMC7395578
has PubMed identifier	32740766
schema:publication	J Neurol
resource representing a document's body	covid:5773cb993bbabdc1c5db06f775e006c723bf368e#body_text
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