About: Hemorrhagic shock and encephalopathy syndrome – the markers for an early HSES diagnosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hemorrhagic shock and encephalopathy syndrome – the markers for an early HSES diagnosis
Creator	Shiomi, Masashi Arimoto, Hideki Fuke, Akihiro Kaji, Arito Kan, Masanori Kubota, Tetsushi Kuki, Ichiro Miyaichi, Toshinori Miyamoto, Satoru Miyazaki, Dai Rinka, Hiroshi Tsuruwa, Miho Yoshida, Takeshi Yoshimoto, Akira
Source	PMC
abstract	BACKGROUND: The hemorrhagic shock and encephalopathy syndrome (HSES) is a devastating disease that affects young children. The outcomes of HSES patients are often fatal or manifesting severe neurological sequelae. We reviewed the markers for an early diagnosis of HSES. METHODS: We examined the clinical, biological and radiological findings of 8 patients (4 months to 9 years old) who met the HSES criteria. RESULTS: Although cerebral edema, disseminated intravascular coagulopathy (DIC), and multiple organ failure were seen in all 8 cases during their clinical courses, brain computed tomography (CT) scans showed normal or only slight edema in 5 patients upon admission. All 8 patients had normal platelet counts, and none were in shock. However, they all had severe metabolic acidosis, which persisted even after 3 hours (median base excess (BE), -7.6 mmol/L). And at 6 hours after admission (BE, -5.7 mmol/L) they required mechanical ventilation. Within 12 hours after admission, fluid resuscitation and vasopressor infusion for hypotension was required. Seven of the patients had elevated liver enzymes and creatine kinase (CK) upon admission. Twenty-four hours after admission, all 8 patients needed vasopressor infusion to maintain blood pressure. CONCLUSION: CT scan, platelet count, hemoglobin level and renal function upon admission are not useful for an early diagnosis of HSES. However, the elevated liver enzymes and CK upon admission, hypotension in the early stage after admission with refractory acid-base disturbance to fluid resuscitation and vasopressor infusion are useful markers for an early HSES diagnosis and helpful to indicate starting intensive neurological treatment.
has issue date	2008-10-16(xsd:dateTime)
bibo:doi	10.1186/1471-2431-8-43
bibo:pmid	18922188
has license	cc-by
sha1sum (hex)	57383b80a4a1b97a7d3cf130525117d08e07c919
schema:url	https://doi.org/10.1186/1471-2431-8-43
resource representing a document's title	Hemorrhagic shock and encephalopathy syndrome – the markers for an early HSES diagnosis
has PubMed Central identifier	PMC2577649
has PubMed identifier	18922188
schema:publication	BMC Pediatr
resource representing a document's body	covid:57383b80a4a1b97a7d3cf130525117d08e07c919#body_text
is schema:about of	named entity 'neurological' named entity 'encephalopathy' named entity 'hemorrhagic shock' named entity 'young children' named entity 'sequelae' named entity 'hemorrhagic shock' named entity 'Hemorrhagic shock' named entity 'encephalopathy' named entity 'norepinephrine' named entity 'AST and ALT' named entity 'white blood cell' named entity 'palliative' named entity 'respiratory function' named entity 'brain edema' named entity 'coma' named entity 'Idro' named entity 'multiple organ failure' named entity 'vascular permeability' named entity 'septic shock' named entity 'cerebral edema' named entity 'infusion' named entity 'brain edema' named entity 'General Hospital' named entity 'early diagnosis' named entity 'diarrhea' named entity 'etiology' named entity 'neurological' named entity 'seizures' named entity 'CVP' named entity 'brain edema' named entity 'hyperventilation' named entity 'intensive treatment' named entity 'renal function' named entity 'infusion' named entity 'μmol' named entity 'metabolic acidosis' named entity 'central venous pressure' named entity 'early diagnosis' named entity 'mmol/L' named entity '2.1' named entity 'cerebral perfusion pressure' named entity 'prognoses' named entity 'barbiturate' named entity 'IL-6' named entity 'ARDS' named entity 'viral pathogens' named entity 'platelet counts' named entity 'septic shock' named entity 'epileptic' named entity 'seizure' named entity 'convulsions' named entity 'sequelae' named entity 'serum lactate' named entity 'intracranial pressure' named entity 'staphylococcal' named entity 'cytokines' named entity 'norepinephrine' named entity 'infusion' named entity 'EEG' named entity 'Brain edema' named entity 'Elevated liver enzymes' named entity 'metabolic acidosis' named entity 'convulsions' named entity 'hemoglobin' named entity 'crystalloid' named entity 'Metabolic acidosis' named entity 'metabolic acidosis' named entity 'metabolic acidosis'

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