About: Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers

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About: Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers
Creator	Bavari, Sina Blouch, Robert Olinger, Gene Iversen, Patrick Aman, M Nichols, Donald Pratt, William Stein, David Swenson, Dana Warfield, Kelly
Source	Medline; PMC
abstract	The filoviruses Marburg virus and Ebola virus (EBOV) quickly outpace host immune responses and cause hemorrhagic fever, resulting in case fatality rates as high as 90% in humans and nearly 100% in nonhuman primates. The development of an effective therapeutic for EBOV is a daunting public health challenge and is hampered by a paucity of knowledge regarding filovirus pathogenesis. This report describes a successful strategy for interfering with EBOV infection using antisense phosphorodiamidate morpholino oligomers (PMOs). A combination of EBOV-specific PMOs targeting sequences of viral mRNAs for the viral proteins (VPs) VP24, VP35, and RNA polymerase L protected rodents in both pre- and post-exposure therapeutic regimens. In a prophylactic proof-of-principal trial, the PMOs also protected 75% of rhesus macaques from lethal EBOV infection. The work described here may contribute to development of designer, “druggable” countermeasures for filoviruses and other microbial pathogens.
has issue date	2006-01-13(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.0020001
bibo:pmid	16415982
has license	no-cc
sha1sum (hex)	5722e1b167fe879fc2901ba8ea2fa69fec89a6f7
schema:url	https://doi.org/10.1371/journal.ppat.0020001
resource representing a document's title	Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers
has PubMed Central identifier	PMC1326218
has PubMed identifier	16415982
schema:publication	PLoS Pathog
resource representing a document's body	covid:5722e1b167fe879fc2901ba8ea2fa69fec89a6f7#body_text
is schema:about of	named entity 'SPECIFIC' named entity 'ANTISENSE' named entity 'EBOV' named entity 'morpholino' named entity 'filoviruses' named entity 'phosphorodiamidate' named entity 'work' named entity 'NONHUMAN PRIMATES' named entity 'DEVELOPMENT' named entity 'VIRAL' named entity 'EFFECTIVE' named entity 'BASED' named entity 'DESCRIBED' named entity 'MARBURG VIRUS ' named entity 'SEQUENCES' named entity 'PRINCIPAL' named entity 'REPORT' named entity 'IMMUNE RESPONSES' named entity 'CHALLENGE' named entity 'KNOWLEDGE' named entity 'RNA POLYMERASE' named entity 'REGIMENS' covid:arg/5722e1b167fe879fc2901ba8ea2fa69fec89a6f7 named entity 'CAUSE' named entity 'FILOVIRUS' named entity 'EXPOSURE' named entity 'GENE' named entity 'EBOLA VIRUS' named entity 'BASED' named entity 'LETHAL' named entity 'POLYMERASE L' named entity 'PROPHYLACTIC' named entity 'NEARLY' named entity 'CASE' named entity 'RODENTS' named entity 'HEMORRHAGIC FEVER' named entity 'USING' named entity 'MRNAS' named entity 'STRATEGY' named entity 'PRE' named entity 'HOST' named entity '90%' named entity 'POST' named entity 'WORK' named entity '100%' named entity 'SUCCESSFUL' named entity 'IS A' named entity 'PROOF' named entity 'TARGETING' named entity 'PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS' named entity 'RATES' named entity 'PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS' named entity 'HERE' named entity 'DESIGNER' named entity 'PUBLIC HEALTH' named entity 'THERAPEUTIC' named entity 'INFECTION' named entity 'ANTISENSE' named entity 'FILOVIRUSES' named entity 'CITATION' named entity 'EBOLA VIRUS' named entity 'HUMANS' named entity 'MICROBIAL PATHOGENS' named entity 'SPECIFIC' named entity 'OF-' named entity 'CONTRIBUTE ' named entity 'TRIAL' named entity 'GENE' named entity 'INTERFERING' named entity 'COMBINATION' named entity 'HIGH' named entity 'VIRAL PROTEINS'

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