About: Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs
Creator	Jiang, Shibo Liu, Keliang Pan, Chungen Shi, Weiguo Qi, Zhi Qie, Jiankun Xue, Na Debnath, Asim
source	Elsevier; Medline; PMC
abstract	The peptidic anti-HIV drug T20 (Fuzeon) and its analog C34 share a common heptad repeat (HR) sequence, but they have different functional domains, i.e., pocket- and lipid-binding domains (PBD and LBD, respectively). We hypothesize that novel anti-HIV peptides may be designed by using artificial sequences containing multiple copies of HR motifs plus zero, one or two functional domains. Surprisingly, we found that the peptides containing only the non-natural HR sequences could significantly inhibit HIV-1 infection, while addition of PBD and/or LBD to the peptides resulted in significant improvement of anti-HIV-1 activity. These results suggest that these artificial HR sequences, which may serve as structural domains, could be used as templates for the design of novel antiviral peptides against HIV and other viruses with class I fusion proteins.
has issue date	2008-10-01(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2008.07.134
bibo:pmid	18682248
has license	green-oa
sha1sum (hex)	5711bdf88311e0ee2a78792dc41cb27e3cb1595d
schema:url	https://doi.org/10.1016/j.bbrc.2008.07.134
resource representing a document's title	Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs
has PubMed Central identifier	PMC2597519
has PubMed identifier	18682248
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:5711bdf88311e0ee2a78792dc41cb27e3cb1595d#body_text
is schema:about of	named entity 'MOTIFS' named entity 'artificially designed' named entity 'REPEAT' named entity 'NOVEL' named entity 'CONTAINING' named entity 'COPIES' named entity 'ANTI-HIV' named entity 'PEPTIDES' named entity 'MULTIPLE' named entity 'heptad repeat' named entity 'Novel' named entity 'heptad repeat' named entity 'anti-HIV' named entity 'HIV-1' named entity 'inhibitory activity' named entity 'peptides' named entity 'MBHA' named entity 'HIV-1' named entity 'HIV-1' named entity 'peptides' named entity 'transmembrane' named entity 'HIV-1' named entity 'effector cells' named entity 'peptides' named entity 'p24 antigen' named entity 'Glu' named entity 'cell-cell' named entity 'potency' named entity 'CHR' named entity 'HIV infection' named entity 'peptides' named entity 'antiviral activity' named entity 'C-terminus' named entity 'HIV-1' named entity 'HIV' named entity 'supernatants' named entity 'peptides' named entity 'fusion proteins' named entity 'Calcein' named entity 'CCR5' named entity 'HIV-1' named entity 'peptides' named entity 'coiled-coil' named entity 'gp41' named entity 'structural domain' named entity 'NHR' named entity 'HIV-1' named entity 'PyMOL' named entity 'Streptavidin' named entity 'gp41' named entity 'peptide' named entity 'interact' named entity 'reverse phase high performance liquid chromatography' named entity 'gp41' named entity 'functional domains' named entity 'dye transfer' named entity 'peptides' named entity 'inhibitory activity' named entity 'motif' named entity 'peptides' named entity 'Secondary structure prediction' named entity 'negatively charged' named entity 'NHR' named entity 'peptides' named entity 'Durham, NC' named entity 'HIV' named entity 'inhibitory activity' named entity 'NHR' named entity 'cell-cell' named entity 'peptide' named entity 'peptide' named entity 'peptides' named entity 'X-ray crystallography' named entity 'motif'

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