About: Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017

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About: Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017
Creator	Wang, Feng Feng, Tiejian Lan, Lina Wu, Xiaobing Zhang, Chunlai Cai, Yumao Fu, Hanlin Guan, Yang Tang, Fen Wu, Fengxin Ye, Jianbin Yu, Weiye
Source	Medline; PMC
abstract	OBJECTIVE: This study investigated the association between syphilis seroprevalence and age among blood donors, and described the distribution of serological titres among syphilis-infected donors, aiming to confirm the syphilis epidemic characteristics and to promote effective interventions for older adults. METHODS: Data were obtained from the Shenzhen Programme for Syphilis Prevention and Control in 2014–2017. Blood samples were screened using the ELISAs, and confirmed using the Treponema pallidum particle agglutination assay (TPPA) and toluidine red unheated serum test (TRUST). RESULTS: Among 394 792 blood donors, 733 tested TPPA and TRUST positive (active infection), and 728 tested only TPPA positive (historical infection). The overall prevalence of syphilis seropositivity was 370.1 per 100 000 (95% CI 351.1 to 389.0 per 100 000); the prevalence of active infection was 185.7 per 100 000 (95% CI 172.2 to 199.1 per 100 000). People aged ≥45 years displayed a prevalence of 621.8 per 100 000 in syphilis seropositivity and 280.5 per 100 000 in active infection, which were 3.8 times and 2.4 times higher than that for people aged <25 years, respectively. The prevalence of syphilis seropositivity (χ(2) (trend)=311.9, p (trend)<0.001) and active infection (χ(2) (trend)=72.1, p (trend)<0.001) increased significantly with age. After stratification by gender and year of donation, the increasing trend of prevalence with age remained (p (trend)<0.05), except for the prevalence of active infection in males and females in 2014. About 16.3% of donors with active infection and aged ≥45 years had a TRUST titre of ≥1∶8, lower than that of patients aged <25 years (51.3%) and 25–34 years (34.1%). CONCLUSIONS: The findings confirm the high prevalence of syphilis among older adults, and suggest the need to increase awareness among healthcare providers and deliver more targeted prevention interventions for older adults to promote early testing.
has issue date	2019-11-02(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2018-024393
bibo:pmid	31678932
has license	cc-by-nc
sha1sum (hex)	56f69c9790f32dd7649fa2e14be26ae099321ee6
schema:url	https://doi.org/10.1136/bmjopen-2018-024393
resource representing a document's title	Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017
has PubMed Central identifier	PMC6830658
has PubMed identifier	31678932
schema:publication	BMJ Open
resource representing a document's body	covid:56f69c9790f32dd7649fa2e14be26ae099321ee6#body_text
is schema:about of	named entity 'syphilis' named entity 'Association' named entity 'blood donors' named entity 'SOUTHERN' named entity 'AGE' named entity 'CHINA' named entity 'OBSERVATIONAL STUDY' named entity 'BLOOD DONORS' named entity 'ASSOCIATION' named entity 'SYPHILIS' named entity 'SEROPREVALENCE' named entity 'Southern China' named entity 'Shenzhen' named entity 'syphilis screening' named entity 'India' named entity 'serostatus' named entity 'sexually transmitted diseases' named entity 'seropositivity' named entity 'Shenzhen' named entity 'HIV' named entity 'transmission rate' named entity 'population samples' named entity 'older people' named entity 'China' named entity 'infection' named entity 'TPPA' named entity 'ELISAs' named entity 'infection' named entity 'seroprevalence' named entity 'syphilis' named entity 'seropositivity' named entity 'general population' named entity 'Clinical examination' named entity 'blood donors' named entity 'screening test' named entity 'infection' named entity 'HIV infection' named entity 'disease burden' named entity 'TPPA' named entity 'syphilis' named entity 'older adults' named entity 'blood donation' named entity 'infection' named entity 'older adults' named entity 'breast feeding' named entity 'transfusion' named entity 'syphilis' named entity 'Shenzhen' named entity 'Shenzhen Special Economic Zone' named entity 'syphilis' named entity 'older people' named entity 'China' named entity 'follow-up' named entity 'cardiovascular syphilis' named entity 'HIV' named entity 'HIV' named entity 'syphilis' named entity 'seropositive' named entity 'Shenzhen' named entity 'Syphilis' named entity 'non-communicable diseases' named entity 'blood donors' named entity 'syphilis screening' named entity 'ageism' named entity 'BioTech' named entity 'syphilis' named entity 'Blood Donation' named entity 'sexual health' named entity 'syphilis' named entity 'delirium'

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