About: The African-American population with a low allele frequency of SNP rs1990760 (T allele) in IFIH1 predicts less IFN-beta expression and potential vulnerability to COVID-19 infection

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About: The African-American population with a low allele frequency of SNP rs1990760 (T allele) in IFIH1 predicts less IFN-beta expression and potential vulnerability to COVID-19 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The African-American population with a low allele frequency of SNP rs1990760 (T allele) in IFIH1 predicts less IFN-beta expression and potential vulnerability to COVID-19 infection
Creator	Maiti, Amit
Source	Medline; PMC
abstract	Covid-19 has caused worldwide devastation. IFIH1 is a pattern recognition receptor that senses coronavirus RNA and triggers interferon production as a first line of viral immune defense. The role of IFIH1 polymorphism, rs1990760 (C>T; aaA946T) in the epidemiology of viral infection is well studied, and the minor allele T resists viral infection. Knock-in mice with mutated IFIH1 protein (946T) for this allele have enhanced interferon production and protection from lethal viral infection. The minor allele frequency (Tmaf) varies widely from Africans (0.06 to 0.35) to Chinese (0.19 to 0.23) to Caucasians (0.56 to 0.69). During the initial days of infection when the social restrictions were not imposed, I show that the infection rate in Italy was lower as expected from its higher Tmaf (0.56) than that in China (Tmaf for southern China, 0.23). The infection rate in the USA and Spain was intermediate between those two countries despite higher Caucasian overall Tmaf (0.69), perhaps due to a more admixed African population in these countries. These analyses suggest that African-Americans and Chinese with low Tmaf of rs1990760 are more vulnerable to SARS-COV2 infection, apart from other genetic factors or socioeconomic conditions in these population. Taken together, an IFN-beta supplement might aid in preventing COVID-19 infection and help in development of herd immunity.
has issue date	2020-07-31(xsd:dateTime)
bibo:doi	10.1007/s00251-020-01174-6
bibo:pmid	32737579
has license	no-cc
sha1sum (hex)	56ef66bed93f720d125a937f000e0184874a0421
schema:url	https://doi.org/10.1007/s00251-020-01174-6
resource representing a document's title	The African-American population with a low allele frequency of SNP rs1990760 (T allele) in IFIH1 predicts less IFN-beta expression and potential vulnerability to COVID-19 infection
has PubMed Central identifier	PMC7394703
has PubMed identifier	32737579
schema:publication	Immunogenetics
resource representing a document's body	covid:56ef66bed93f720d125a937f000e0184874a0421#body_text
is schema:about of	named entity 'immune' named entity 'production' named entity 'socioeconomic' named entity 'IFIH1' named entity 'LOW' named entity 'KNOCK-IN MICE' named entity 'TAKEN' named entity 'LOWER' named entity 'DAYS' named entity 'PROTECTION' named entity 'SOCIOECONOMIC' named entity 'APART' named entity 'Chinese' named entity 'development' named entity 'African' named entity 'Caucasian' named entity 'USA' named entity 'analyses' named entity 'worldwide devastation' named entity 'infection' named entity 'lethal' named entity 'production' named entity 'interferon' named entity 'China' named entity 'immune defense' named entity 'allele' named entity 'genetic factors' named entity 'minor allele frequency' named entity 'interferon' named entity 'worldwide devastation' named entity 'pattern recognition receptor' named entity 'infection' named entity 'Spain' named entity 'IFIH1' named entity 'IFN' named entity 'COVID-19 infection' named entity 'SARS' named entity 'Hong Kong' named entity 'infection rate' named entity 'China' named entity 'multiple sclerosis' named entity 'virus' named entity 'IFN-beta' named entity 'genotype-phenotype' named entity 'coronavirus' named entity 'IFIH1' named entity 'Asian' named entity 'upper respiratory tract' named entity 'genotyping' named entity 'African-American' named entity 'RNA genome' named entity 'mortality rate' named entity 'viral infection' named entity 'cell culture' named entity 'Spain' named entity 'infection' named entity 'protein' named entity 'genetic material' named entity 'IFIH1' named entity 'infection' named entity 'type 1 IFN' named entity 'sequence alignment' named entity 'infection' named entity 'protein synthesis' named entity 'Italy' named entity 'infection' named entity 'SARS' named entity 'rhinovirus' named entity 'InterFeron' named entity 'IFIH1' named entity 'SARS' named entity 'RNA' named entity 'Italy' named entity 'IFIH1' named entity 'dengue virus' named entity 'SARS' named entity 'polymorphism' named entity 'Middle East Respiratory Syndrome' named entity 'infection' named entity 'infection' named entity 'orthologue'

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