About: Preliminary investigation demonstrating the GHITM gene probably involved in apoptosis and growth of the golden apple snail (Pomacea canaliculata)

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About: Preliminary investigation demonstrating the GHITM gene probably involved in apoptosis and growth of the golden apple snail (Pomacea canaliculata) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Preliminary investigation demonstrating the GHITM gene probably involved in apoptosis and growth of the golden apple snail (Pomacea canaliculata)
Creator	Wang, Xiaona Wang, Xiaotong Wei, Lei He, Cheng Li, Lingling Guo, Wen Jiang, Qiuyun Song, Hongce Yu, Wenchao Zhan, Rui Zhang, Baolu Zhao, Nannan
source	PMC
abstract	BACKGROUND: Growth hormone inducible transmembrane protein (GHITM) is a highly conserved transmembrane protein. This study was conducted to investigate the role of GHITM gene in the apoptosis and growth of the golden apple snail Pomacea canaliculate. RESULTS: The complete cDNA of this gene was cloned using the rapid amplification of cDNA ends (RACE) method and subjected to bioinformatics analysis. The full-length cDNA was 2242 bp, including an open reading frame of 1021 bp that encoded a protein of 342 amino acid residues. The mRNA expression profiles of GHITM gene in different tissues (liver, kidney, gonad and foot) and different growth phases (6-months old and 2-years old) showed that it was expressed in various tissues and different growth phases. Silencing of the GHITM gene by RNAi (RNA interference) experiments revealed that the GHITM gene possibly plays a role in inhibiting apoptosis through detecting the Caspase (Cysteine-requiring Aspartate Protease)-3 activity. In addition, the aperture width and body whorl length of the snail was significantly affected by RNAi, suggesting that this gene plays a significant role in promoting the growth of the organism. CONCLUSIONS: These results demonstrated that the GHITM gene was involved in apoptosis and growth in golden apple snail.
has issue date	2020-01-06(xsd:dateTime)
bibo:doi	10.1186/s12864-019-6434-2
bibo:pmid	31906861
has license	cc-by
sha1sum (hex)	564c7e1d73e53496f5212f5935a360b8c7a6b4ab
schema:url	https://doi.org/10.1186/s12864-019-6434-2
resource representing a document's title	Preliminary investigation demonstrating the GHITM gene probably involved in apoptosis and growth of the golden apple snail (Pomacea canaliculata)
has PubMed Central identifier	PMC6945724
has PubMed identifier	31906861
schema:publication	BMC Genomics
resource representing a document's body	covid:564c7e1d73e53496f5212f5935a360b8c7a6b4ab#body_text
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