About: Lung diseases after bone marrow transplantation: Results of a clinical, radiological, histological, immunological and lung function study

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About: Lung diseases after bone marrow transplantation: Results of a clinical, radiological, histological, immunological and lung function study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lung diseases after bone marrow transplantation: Results of a clinical, radiological, histological, immunological and lung function study
Creator	Schneider, E Link, H Niethammer, D Wernet, P Blaurock, M Fischbach, H Karls, Eberhard Ostendorf, P Reinhard, U Walter, E Wilms, K
Source	PMC
abstract	The case histories of 72 subsequently treated patients — 44 with acute leukemia, 10 with chronic myeloid leukemia, 16 with severe aplastic anemia and 2 with neuroblastoma — were analyzed after bone marrow transplantation (BMT) with respect to pulmonary diseases. Thirty-eight patients suffered from a total of 51 pulmonary complications, which led to death in 20. Of 13 patients, 3 died of bacterial pneumonia, all of them during granulocytopenia; 2 of 6 patients died of fungal pneumonia and 2 out of 3 of a mixed bacterialmycotic infection. Adult respiratory distress syndrome (ARDS) led to death in 2 patients. A granulocyte count under 500/µl correlated significantly (P<0.002) with the fatal outcome of bacterial, fungal and ARDS pneumonia as well as with bronchitis. Viral pneumonia led to death in 8 of 9 patients; in each there was a significant correlation (P<0.05) with graft-versus-host disease (GvHD). Patients with repeated episodes of pulmonary illness had significantly more chronic GvHD (P<0.05); several of these patients displayed a reduction in helper T cells and an increase in suppressor T cells in the peripheral blood. The natural killer (NK) cells were reduced and the percentage of activated NK cell level lay between 6% and 69%. B-cells were absent or deficient. These findings explain in part the absence of specific antibody reactivity. Five of these patients also contracted GvHD-associated obstructive bronchiolitis, which did not respond to therapy. Pulmonary infiltrates of unknown origin (including idiopathic interstitial pneumonia) occurred in 8 of the patients (11.1%), with a fatal outcome in 3 patients. Significant changes (P<0.05) in lung function after BMT appeared in the form of reduced vital capacity (VC) increased residual volume (RV) and an increase in RV expressed as the percentage of total lung capacity. Pulmonary diseases were the most common complication and cause of death in our patients after BMT.
has issue date	1986-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01735262
bibo:pmid	3528653
has license	no-cc
sha1sum (hex)	5607fc4c985946200338ad99c4bc2041865dd41c
schema:url	https://doi.org/10.1007/bf01735262
resource representing a document's title	Lung diseases after bone marrow transplantation: Results of a clinical, radiological, histological, immunological and lung function study
has PubMed Central identifier	PMC7095942
has PubMed identifier	3528653
schema:publication	Klin Wochenschr
resource representing a document's body	covid:5607fc4c985946200338ad99c4bc2041865dd41c#body_text
is schema:about of	named entity 'pulmonary' named entity 'bacterial' named entity 'Results' named entity 'SIGNIFICANT' named entity 'NATURAL KILLER' named entity 'FATAL OUTCOME' named entity 'MIXED' named entity 'infection' named entity 'patients' named entity 'Adult' named entity 'Patients' named entity 'chronic' named entity 'graft-versus-host disease' named entity 'fatal' named entity 'The natural' named entity 'BMT' named entity 'pulmonary diseases' named entity 'treated' named entity 'ARDS' named entity 'pulmonary complications' named entity 'peripheral blood' named entity 'ARDS' named entity 'acute leukemia' named entity 'BMT' named entity 'chronic myeloid leukemia' named entity 'granulocytopenia' named entity 'granulocyte' named entity 'Lung Function' named entity 'Bone Marrow Transplantation' named entity 'inducer' named entity 'BMT' named entity 'complement' named entity 'cm H20' named entity 'sepsis' named entity 'correlation' named entity 'CMV' named entity 'cyclosporin' named entity 'idiopathic interstitial pneumonia' named entity 'serum' named entity 'bronchiolitis obliterans' named entity 'bronchiolar epithelium' named entity '21 days' named entity 'bacterial pneumonia' named entity 'thoracic' named entity 'Histology' named entity 'pneumonia' named entity 'HLA' named entity 'Histologically' named entity 'body weight' named entity 'VZV' named entity 'Klebsiella' named entity 'pathogens' named entity 'Lung function tests' named entity 'suppressor T cells' named entity 'BMT' named entity 'interleukin 2' named entity 'cutaneous' named entity 'single-cell' named entity 'bacterial pneumonia' named entity 'infection' named entity 'pneumonia' named entity 'GvHD' named entity 'pulmonary complications' named entity 'FEV1' named entity 'SRAW' named entity 'Rel' named entity 'NK cells' named entity 'BMT' named entity 'PAS' named entity 'Lung function' named entity 'fibrin'

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