About: Use of Piezoelectric Immunosensors for Detection of Interferon-Gamma Interaction with Specific Antibodies in the Presence of Released-Active Forms of Antibodies to Interferon-Gamma

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About: Use of Piezoelectric Immunosensors for Detection of Interferon-Gamma Interaction with Specific Antibodies in the Presence of Released-Active Forms of Antibodies to Interferon-Gamma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Use of Piezoelectric Immunosensors for Detection of Interferon-Gamma Interaction with Specific Antibodies in the Presence of Released-Active Forms of Antibodies to Interferon-Gamma
Creator	Barykina, Darya Borshcheva, Alena Don, Elena Epstein, Oleg Ermolaeva, Tatyana Farafonova, Olga Nikiforova, Marina Pokhil, Suzanna Shulga, Darya Tarasov, Sergey
source	PMC
abstract	In preliminary ELISA studies where released-active forms (RAF) of antibodies (Abs) to interferon-gamma (IFNg) were added to the antigen-antibody system, a statistically significant difference in absorbance signals obtained in their presence in comparison to placebo was observed. A piezoelectric immunosensor assay was developed to support these data and investigate the effects of RAF Abs to IFNg on the specific interaction between Abs to IFNg and IFNg. The experimental conditions were designed and optimal electrode coating, detection circumstances and suitable chaotropic agents for electrode regeneration were selected. The developed technique was found to provide high repeatability, intermediate precision and specificity. The difference between the analytical signals of RAF Ab samples and those of the placebo was up to 50.8%, whereas the difference between non-specific controls and the placebo was within 5%–6%. Thus, the piezoelectric immunosensor as well as ELISA has the potential to be used for detecting the effects of RAF Abs to IFNg on the antigen-antibody interaction, which might be the result of RAF’s ability to modify the affinity of IFNg to specific/related Abs.
has issue date	2016-01-20(xsd:dateTime)
bibo:doi	10.3390/s16010096
bibo:pmid	26791304
has license	cc-by
sha1sum (hex)	55a2b6184753d85b19f0425ac2d68868e73248b7
schema:url	https://doi.org/10.3390/s16010096
resource representing a document's title	Use of Piezoelectric Immunosensors for Detection of Interferon-Gamma Interaction with Specific Antibodies in the Presence of Released-Active Forms of Antibodies to Interferon-Gamma
has PubMed Central identifier	PMC4732129
has PubMed identifier	26791304
schema:publication	Sensors (Basel)
resource representing a document's body	covid:55a2b6184753d85b19f0425ac2d68868e73248b7#body_text
is schema:about of	named entity 'ANTIBODIES' named entity 'RELEASED' named entity 'ACTIVE' named entity 'INTERACTION' named entity 'DETECTION' named entity 'FORMS' named entity 'SPECIFIC' named entity 'INTERFERON-GAMMA' named entity 'USE OF' named entity 'PRESENCE OF' named entity 'Interferon-Gamma' named entity 'Piezoelectric' named entity 'Antibodies' named entity 'phosphate-buffered saline' named entity 'lactose' named entity 'triazine' named entity 'centrifugation' named entity 'Russia' named entity 'antibodies' named entity 'non-specific' named entity 'data acquisition' named entity 'IFNg' named entity 'antibodies' named entity 'IFNg' named entity 'ng/mL' named entity 'bacteria' named entity 'ionic strength' named entity 'lactose' named entity 'Utrecht' named entity 'ethanol' named entity 'Moscow' named entity 'IFNg' named entity 'quartz crystal' named entity 'mechanism of action' named entity 'Germany' named entity 'IFNg' named entity 'room temperature' named entity 'IFNg' named entity 'IFNg' named entity 'IFNg' named entity 'TNFa' named entity 'lactose' named entity 'potassium' named entity 'binding constant' named entity 'European Pharmacopoeia' named entity 'oscillation frequency' named entity 'IFNg' named entity 'time period' named entity 'Sigma-Aldrich' named entity 'test sample' named entity 'antigens' named entity 'active sites' named entity 'one-way analysis of variance' named entity 'receptor molecules' named entity 'sensor' named entity 'IFNg' named entity 'Russia' named entity 'Berlin' named entity 'biomolecules' named entity 'water solution' named entity 'IFNg' named entity 'IFNg' named entity 'IFNg' named entity 'receptor layer' named entity 'placebo' named entity 'immunosensor' named entity 'diclofenac' named entity 'non-clinical' named entity 'diclofenac' named entity 'non-specific' named entity 'IFNg' named entity 'placebo'

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