About: Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia

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About: Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia—a new therapeutic strategy? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia—a new therapeutic strategy?
Creator	Herold, Susanne Rösler, Barbara
Source	PMC
abstract	Influenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics cause massive morbidity and mortality worldwide. Infection may result in rapid progressive viral pneumonia with fatal outcome. Since accurate treatment strategies are still missing, research refocuses attention to lung pathology and cellular crosstalk to develop new therapeutic options. Alveolar epithelial cells (AECs) play an important role in orchestrating the pulmonary antiviral host response. After IV infection they release a cascade of immune mediators, one of which is granulocyte and macrophage colony-stimulating factor (GM-CSF). GM-CSF is known to promote differentiation, activation and mobilization of myeloid cells. In the lung, GM-CSF drives immune functions of alveolar macrophages and dendritic cells (DCs) and also improves epithelial repair processes through direct interaction with AECs. During IV infection, AEC-derived GM-CSF shows a lung-protective effect that is also present after local GM-CSF application. This mini-review provides an overview on GM-CSF-modulated immune responses to IV pneumonia and its therapeutic potential in severe IV pneumonia.
has issue date	2016-08-01(xsd:dateTime)
bibo:doi	10.1186/s40348-016-0055-5
bibo:pmid	27480877
has license	cc-by
sha1sum (hex)	559137ce86d7c2cd8c3dc5b614f3d2dd001fea04
schema:url	https://doi.org/10.1186/s40348-016-0055-5
resource representing a document's title	Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia—a new therapeutic strategy?
has PubMed Central identifier	PMC4969252
has PubMed identifier	27480877
schema:publication	Mol Cell Pediatr
resource representing a document's body	covid:559137ce86d7c2cd8c3dc5b614f3d2dd001fea04#body_text
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