About: Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein

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About: Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
Creator	Enjuanes, Luis Fernandez-Delgado, Raul Bosch, Berend-Jan Li, Wentao Widjaja, Ivy Wang, Chunyan Drabek, Dubravka Grosveld, Frank Gutiérrez-Álvarez, Javier Haagmans, Bart Okba, Nisreen Stalin Raj, V Van Kuppeveld, Frank Van Dieren, Brenda Van Haperen, Rien
Source	Medline; PMC
abstract	The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target the receptor binding domain of the viral spike protein thereby blocking receptor binding. Here, we developed a set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere with the three critical entry functions of the MERS-CoV spike protein: sialic acid binding, receptor binding and membrane fusion. Passive immunization with potently as well as with poorly neutralizing antibodies protected mice from lethal MERS-CoV challenge. Collectively, these antibodies offer new ways to gain humoral protection in humans against the emerging MERS-CoV by targeting different spike protein epitopes and functions.
has issue date	2019-04-02(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1597644
bibo:pmid	30938227
has license	cc-by
sha1sum (hex)	5581ec03ebdca073e13b0df6329779940908f038
schema:url	https://doi.org/10.1080/22221751.2019.1597644
resource representing a document's title	Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
has PubMed Central identifier	PMC6455120
has PubMed identifier	30938227
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:5581ec03ebdca073e13b0df6329779940908f038#body_text
is schema:about of	named entity 'focused' named entity 'fatal' named entity 'functions' named entity 'solution' named entity 'monoclonal antibodies' named entity 'functions' named entity 'SOLUTION' named entity 'CORONAVIRUS' named entity 'EPITOPES' named entity 'OFFER' named entity 'PROTECTION' named entity 'NEUTRALIZING ANTIBODIES' named entity 'CORONAVIRUS' named entity 'DOMAIN' named entity 'CHALLENGE' named entity 'THERAPIES' named entity 'LETHAL' named entity 'CAUSES' named entity 'TARGET' named entity 'ANTIBODIES' named entity 'INTERFERE' named entity 'HUMANS' named entity 'GAIN' named entity 'MIDDLE' named entity 'MEMBRANE FUSION' named entity 'EPITOPE' named entity 'VIRAL' named entity 'CRITICAL' named entity 'NEW' named entity 'MERS-COV' named entity 'DISTINCT' named entity 'SPIKE PROTEIN' named entity 'FATAL' named entity 'BLOCKING' named entity 'PROTEIN ' named entity 'HAVE' named entity 'BASED' named entity 'SET' named entity 'RECEPTOR BINDING' named entity 'EAST' named entity 'THESE' named entity 'GROUPS' named entity 'FUNCTIONS' named entity 'MONOCLONAL ANTIBODIES' named entity 'MERS' named entity 'FUNCTIONS' named entity 'MONOCLONAL ANTIBODIES' named entity 'MICE' named entity 'ZOONOTIC' named entity 'RESPIRATORY DISEASE' named entity 'IS A' named entity 'ANTIBODY' named entity 'HUMAN' named entity 'TARGETING' named entity 'DIFFERENT' named entity 'HUMAN' named entity 'FOCUSED' named entity 'VIRUS' named entity 'POORLY' named entity 'PASSIVE IMMUNIZATION' named entity 'SYNDROME' named entity 'SEVERE' named entity 'ENTRY' named entity 'SIALIC ACID BINDING' named entity 'RESPIRATORY' named entity 'TARGETING' named entity 'HERE'

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