About: Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

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About: Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target
Creator	Dijkman, Ronald Schmolke, Mirco Yángüez, Emilio Elshina, Elizaveta Gehrig, Peter Grossmann, Jonas Hunziker, Annika Karakus, Umut Schading, Simon Stertz, Silke Yildiz, Soner Dobay, Maria
Source	PMC
abstract	Although annual influenza epidemics affect around 10% of the global population, current treatment options are limited and development of new antivirals is needed. Here, using quantitative phosphoproteomics, we reveal the unique phosphoproteome dynamics that occur in the host cell within minutes of influenza A virus (IAV) infection. We uncover cellular kinases required for the observed signaling pattern and find that inhibition of selected candidates, such as the G protein-coupled receptor kinase 2 (GRK2), leads to decreased IAV replication. As GRK2 has emerged as drug target in heart disease, we focus on its role in IAV infection and show that it is required for viral uncoating. Replication of seasonal and pandemic IAVs is severely decreased by specific GRK2 inhibitors in primary human airway cultures and in mice. Our study reveals the IAV-induced changes to the cellular phosphoproteome and identifies GRK2 as crucial node of the kinase network that enables IAV replication.
has issue date	2018-09-11(xsd:dateTime)
bibo:doi	10.1038/s41467-018-06119-y
bibo:pmid	30206219
has license	cc-by
sha1sum (hex)	554d4209692f1b384ec738f3c74b110ccf5e8dbb
schema:url	https://doi.org/10.1038/s41467-018-06119-y
resource representing a document's title	Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target
has PubMed Central identifier	PMC6133941
has PubMed identifier	30206219
schema:publication	Nat Commun
resource representing a document's body	covid:554d4209692f1b384ec738f3c74b110ccf5e8dbb#body_text
is schema:about of	named entity 'cellular' named entity 'host' named entity 'kinase' named entity 'antiviral drug' named entity 'EARLY' named entity 'DRUG TARGET' named entity 'HEART DISEASE' named entity 'G PROTEIN-COUPLED RECEPTOR KINASE 2' named entity 'PRIMARY' named entity 'AIRWAY' named entity '10%' named entity 'STUDY' named entity 'DEVELOPMENT' named entity 'INFLUENZA A VIRUS' named entity 'MINUTES' named entity 'KINASE' named entity 'ANTIVIRALS' named entity 'QUANTITATIVE' named entity 'INHIBITORS' named entity 'HERE' named entity 'INHIBITION' named entity 'REVEAL' named entity 'GRK2' named entity 'DYNAMICS' named entity 'VIRAL UNCOATING' named entity 'DRUG TARGET' named entity 'REQUIRED' named entity 'INFECTION' named entity 'LIMITED' named entity 'OUR' named entity 'EPIDEMICS' named entity 'HUMAN' named entity 'INDUCED' named entity 'ENABLES' named entity 'PATTERN' named entity 'ROLE' named entity 'PANDEMIC' named entity 'NEEDED' named entity 'PHOSPHOPROTEOMICS' named entity 'PHOSPHOPROTEOME' named entity 'ANTIVIRAL DRUG' named entity 'INFLUENZA VIRUS' named entity 'TREATMENT OPTIONS' named entity 'BASED' named entity 'KINASE' named entity 'VIRUS INFECTION' named entity 'SELECTED' named entity 'SPECIFIC' named entity 'CHANGES' named entity 'INFLUENZA' named entity 'POPULATION' named entity 'CURRENT TREATMENT' named entity 'AFFECT' named entity 'OCCUR' named entity 'NETWORK' named entity 'NEW' named entity 'LEADS' named entity 'FOCUS' named entity 'CULTURES' named entity 'CELLULAR' named entity 'NODE' named entity 'ANNUAL' named entity 'UNIQUE' named entity 'HOST CELL' named entity 'DECREASED' named entity 'ITS' named entity 'GRK2' named entity 'SIGNALING' named entity 'REPLICATION' named entity 'OBSERVED'

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