About: De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery

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About: De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery
Creator	Jiang, Shibo Wang, Chao Zhong, Wu Xia, Shuai Liang, Guodong Zhao, Lei Liu, Keliang Zhang, Tianhong Cao, Ruiyuan Li, Yue Meng, Guangpeng Shi, Weiguo Wang, Weicong
Source	Medline; PMC
abstract	[Image: see text] Class I enveloped viruses share similarities in their apparent use of a hexameric coiled-coil assembly to drive the merging of virus and host cell membranes. Inhibition of coiled coil-mediated interactions using bioactive peptides that replicate an α-helical chain from the viral fusion machinery has significant antiviral potential. Here, we present the construction of a series of lipopeptides composed of a de novo heptad repeat sequence-based α-helical peptide plus a hydrocarbon tail. Promisingly, the constructs adopted stable α-helical conformations and exhibited relatively broad-spectrum antiviral activities against Middle East respiratory syndrome coronavirus (MERS-CoV) and influenza A viruses (IAVs). Together, these findings reveal a new strategy for relatively broad-spectrum antiviral drug discovery by relying on the tunability of the α-helical coiled-coil domains present in all class I fusion proteins and the amphiphilic nature of the individual helices from this multihelix motif.
has issue date	2018-09-07(xsd:dateTime)
bibo:doi	10.1021/acs.jmedchem.8b00890
bibo:pmid	30192544
has license	green-oa
sha1sum (hex)	54f1fd5d2fc81ab76c7139c4d3d2605d085d3e54
schema:url	https://doi.org/10.1021/acs.jmedchem.8b00890
resource representing a document's title	De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery
has PubMed Central identifier	PMC7075651
has PubMed identifier	30192544
schema:publication	Journal of Medicinal Chemistry
resource representing a document's body	covid:54f1fd5d2fc81ab76c7139c4d3d2605d085d3e54#body_text
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