About: Reduced incidence of pneumonia in influenza-vaccinated solid organ transplant recipients with influenza disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reduced incidence of pneumonia in influenza-vaccinated solid organ transplant recipients with influenza disease
Creator	Moreno, A Cordero, E Aydillo, T Bodro, M Fariñ As, M Gavaldà, J Ló Pez-Medrano, F Montejo, M Muñ Oz, P Pachon, J Perez-Ordoñ Ez, A Perez-Romero, P
Source	Elsevier; Medline; PMC
abstract	Whether influenza vaccination influences the severity of illness in cases of clinical failure in solid organ transplant (SOT) recipients receiving influenza vaccine has not been extensively studied. Our goal was to evaluate the frequency of influenza vaccination among SOT recipients with influenza disease and its impact on the illness severity during the 2010–2011 season. Adult SOT recipients with confirmed influenza infection were included from December 2010 to April 2011. Follow-up data were recorded and antibody titres were determined using a microneutralization assay. Sixty-four SOT recipients were included in the study, ten (15.6%) with severe disease, requiring admission to intensive care units, of whom four (6.3%) died. In all, 34 (53.1%) received the 2010–2011 seasonal influenza vaccine and 32 (50.0%) received the 2009-H1N1 pandemic vaccine, and none had detectable antibodies against influenza at the time of diagnosis of influenza infection. Twenty-three (67.6%) of the patients that received the vaccine required hospital admission and presented less dyspnoea (10, 29.4% versus 14 (50.0%), p 0.09) and pneumonia (8, 23.8% versus 15, 50.0%, p 0.03, relative risk 0.3, 95% CI 0.1-0.9) than unvaccinated patients, with relative risk reductions of 60% and 70%, respectively. Although influenza vaccination confers protection on SOT recipients against developing influenza pneumonia, the rate of clinical failure is still high. New strategies to improve influenza immunization are needed for this group of patients.
has issue date	2014-12-25(xsd:dateTime)
bibo:doi	10.1111/1469-0691.12044
bibo:pmid	23078072
has license	no-cc
sha1sum (hex)	54ef6df14c66f19ba128ce0b0b3d2aeeb02115b0
schema:url	https://doi.org/10.1111/1469-0691.12044
resource representing a document's title	Reduced incidence of pneumonia in influenza-vaccinated solid organ transplant recipients with influenza disease
has PubMed Central identifier	PMC7129853
has PubMed identifier	23078072
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:54ef6df14c66f19ba128ce0b0b3d2aeeb02115b0#body_text
is schema:about of	named entity 'pandemic vaccine' named entity 'influenza infection' named entity 'influenza vaccination' named entity 'SOT' named entity 'influenza infection' named entity '2009-H1N1' named entity 'influenza' named entity 'influenza vaccination' named entity 'immunization' named entity 'influenza' named entity '2009-H1N1' named entity 'respiratory illness' named entity 'influenza infection' named entity 'Legionella pneumophila' named entity 'infection' named entity 'influenza' named entity 'comorbidities' named entity 'observational study' named entity 'co-infection' named entity 'vaccine' named entity 'respiratory symptoms' named entity 'influenza infection' named entity 'GMT' named entity 'influenza' named entity 'respiratory symptoms' named entity 'sputum culture' named entity 'enterovirus' named entity 'rhinovirus' named entity 'antiviral therapy' named entity 'SOT' named entity 'viral shedding' named entity 'influenza-like illness' named entity 'mortality rate' named entity 'microbiological' named entity 'influenza' named entity 'OC43' named entity 'prospective cohort' named entity 'SOT' named entity 'cough' named entity 'prognostic' named entity 'influenza epidemic' named entity 'S. pneumoniae' named entity 'transplant recipients' named entity 'epidemic' named entity 'cough' named entity '2009-H1N1' named entity 'allograft' named entity 'antibody' named entity 'biochemical analysis' named entity 'influenza' named entity 'influenza' named entity 'rate of mortality' named entity 'influenza vaccine' named entity 'SOT' named entity 'risk factors' named entity 'septic shock' named entity 'vaccination' named entity 'liver' named entity 'immunosuppressive therapy' named entity 'transbronchial' named entity '1, 2' named entity 'influenza vaccination' named entity 'RT-PCR' named entity 'SOT' named entity 'vaccination' named entity 'Antibody' named entity 'senescence' named entity 'influenza vaccination' named entity 'follow-up' named entity 'Influenza'

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