About: Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides

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About: Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides
Creator	Balzarini, Jan Andrei, Graciela Snoeck, Robert Hamada, Manabu Roy, Vincent Urbina-Blanco, Cesar Whitaker, Tony Schinazi, Raymond Agrofoglio, Luigi Mcbrayer, Tamara Nolan, Steven
Source	Elsevier; Medline; PMC
abstract	Abstract A series of seventeen hitherto unknown ANP analogs bearing the (E)-but-2-enyl aliphatic side chain and modified heterocyclic base such as cytosine and 5-fluorocytosine, 2-pyrazinecarboxamide, 1,2,4-triazole-3-carboxamide or 4-substituted-1,2,3-triazoles were prepared in a straight approach through an olefin acyclic cross metathesis as key synthetic step. All novel compounds were evaluated for their antiviral activities against a large number of DNA and RNA viruses including herpes simplex virus type 1 and 2, varicella zoster virus, feline herpes virus, human cytomegalovirus, hepatitis C virus (HCV), HIV-1 and HIV-2. Among these molecules, only compound 31 showed activity against human cytomegalovirus in HEL cell cultures with at EC50 of ∼10 μM. Compounds 8a, 13, 14, and 24 demonstrated pronounced anti-HCV activity without significant cytotoxicity at 100 μM.
has issue date	2013-09-30(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2013.06.053
bibo:pmid	23911854
has license	els-covid
sha1sum (hex)	54eb56905c73288fb5eae2c9e529873273562756
schema:url	https://doi.org/10.1016/j.ejmech.2013.06.053
resource representing a document's title	Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides
has PubMed Central identifier	PMC7111275
has PubMed identifier	23911854
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:54eb56905c73288fb5eae2c9e529873273562756#body_text
is schema:about of	named entity 'NUCLEOSIDES' named entity 'ANTIVIRAL' named entity 'cytosine' named entity 'cross metathesis' named entity 'straight' named entity 'substituted' named entity 'ANALOGS' covid:arg/54eb56905c73288fb5eae2c9e529873273562756 named entity 'EVALUATION' named entity 'STEP' named entity 'PREPARED' named entity 'MODIFIED' named entity 'ALIPHATIC' named entity 'APPROACH' named entity 'BROAD SPECTRUM' named entity 'STRAIGHT' named entity 'TRIAZOLE' named entity 'BIS' named entity '2-PYRAZINECARBOXAMIDE' named entity 'ACYCLIC' named entity 'SYNTHESIS' named entity 'ANP' named entity 'SEVENTEEN' named entity 'CYTOSINE' named entity 'CROSS METATHESIS' named entity 'OLEFIN' named entity 'PRODRUGS' named entity '2C4' named entity 'CARBOXAMIDE' named entity 'HETEROCYCLIC BASE' named entity 'UNKNOWN' named entity 'BEARING' named entity 'SIDE CHAIN' named entity 'TRIAZOLES' named entity 'SERIES' named entity 'KEY' named entity 'SYNTHETIC' named entity 'ACYCLIC' named entity '5-FLUOROCYTOSINE' named entity 'NOVEL' named entity 'BUT' named entity 'synthetic' named entity 'series' named entity '5-fluorocytosine' named entity 'pyrazinecarboxamide' named entity 'side chain' named entity 'pyrazinecarboxamide' named entity 'heterocyclic base' named entity '1,2,3-triazoles' named entity '5-fluorocytosine' named entity 'nucleosides' named entity 'broad spectrum' named entity 'prodrugs' named entity '1,2,4-triazole' named entity 'POM' named entity 'antiviral' named entity 'aliphatic' named entity 'olefin' named entity 'carboxamide' named entity 'cytosine' named entity 'cross metathesis' named entity 'analogs' named entity 'heterocyclic' named entity 'modified' named entity 'olefin' named entity 'step' named entity 'key' named entity 'carboxamide' named entity '1,2,3-triazoles' named entity 'spectrum' named entity 'nucleosides'

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