About: COVID-19 induced liver function abnormality associates with age

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19 induced liver function abnormality associates with age
Creator	Li, Ming Zhang, Zhenhua Li, Jinsong Lin, Wenyu Han, Mingfeng Holmes, Jacinta Li, Shasha Li, Xiuyong Shao, Tuo Tan, Lin
source	Medline; PMC
abstract	Background: Coronavirus disease 2019 (COVID-19) is a novel infectious disease that may cause fever, dry cough, fatigue and shortness of breath. The impact of COVID-19 on liver function is not well described. Results: We found that the overall frequency of LFT abnormality was 17.6%. Frequency of LFT abnormality was significantly greater in patients with severe/critical (SC) COVID-19 compared to those with mild/moderate (MM) COVID-19 (32.4% vs 11.6%, p=0.011). Among patients with LFT abnormality, the median age was significantly higher in the SC group compared to the MM group (52 vs 39 years, p=0.021). Conclusion: COVID-19 is frequently associated with mild liver function abnormality, particularly in individuals with severe/critical COVID-19 who were older. Liver function should be monitored carefully during infection, with judicious use of hepatotoxic agents where possible and avoidance of prolonged hypotension to minimize liver injury in older patients. Methods: The No. 2 People’s Hospital of Fuyang City in China has admitted a total of 159 patients with confirmed COVID-19 since the outbreak from January 2020 to March 2020. We analyzed the incidence of liver function test (LFT) abnormality in these patients with confirmed COVID-19 infection.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.18632/aging.103720
bibo:pmid	32721928
has license	cc-by
sha1sum (hex)	54aa574557a10d05e22c5f6415dc08004ca9d8df
schema:url	https://doi.org/10.18632/aging.103720
resource representing a document's title	COVID-19 induced liver function abnormality associates with age
has PubMed Central identifier	PMC7425469
has PubMed identifier	32721928
schema:publication	Aging (Albany NY)
resource representing a document's body	covid:54aa574557a10d05e22c5f6415dc08004ca9d8df#body_text
is schema:about of	named entity 'patients' named entity 'moderate' named entity 'injury' named entity 'abnormality' named entity 'March' named entity 'compared' named entity 'liver' named entity 'total' named entity 'function' named entity 'COVID-19' named entity 'patients' named entity 'median age' named entity 'abnormality' named entity 'hepatotoxic' named entity 'mild' named entity 'incidence' named entity 'minimize' named entity 'Liver' named entity 'fatigue' named entity 'severe' named entity 'COVID-19' named entity 'greater' named entity 'SC group' named entity 'individuals' named entity 'COVID-19' named entity 'LFT' named entity 'infection' named entity 'older patients' named entity 'liver function test' named entity 'COVID' named entity 'hypotension' named entity 'infectious disease' named entity 'LFT' named entity 'shortness of breath' named entity 'COVID' named entity 'COVID-19' named entity 'LFT' named entity 'shortness of breath' named entity 'LFT' named entity 'LFTs' named entity 'TBIL' named entity 'Clinical Trial' named entity 'respiratory rate' named entity 'organ' named entity 'gamma-glutamyl transferase' named entity 'hepatocytes' named entity 'hepatitis' named entity 'lung' named entity 'liver' named entity 'week 0' named entity 'influenza' named entity 'liver function test' named entity 'liver function test' named entity 'Italy' named entity 'prothrombin time' named entity 'fatigue' named entity 'liver failure' named entity 'older patients' named entity 'autopsy' named entity 'liver' named entity 'Biotechnology' named entity 'China' named entity 'liver impairment' named entity 'COVID' named entity 'respiratory failure' named entity 'public health' named entity 'interquartile range' named entity 'liver enzymes' named entity 'Shanghai' named entity 'liver function' named entity 'SARS' named entity 'lopinavir/ritonavir'

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