About: Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns

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About: Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns
Creator	Calvelage, Sten Smreczak, Marcin Conrad, Martin Fehlner-Gardiner, Susan Freuling, Thomas Höper, Pawel Müller, Christine Nadin-Davis, Dirk Orlowska, Anna Trebas,
Source	Medline; PMC
abstract	Rabies in wildlife has been successfully controlled in parts of Europe and North America using oral rabies vaccination, i.e., the distribution of baits containing live-attenuated virus strains. Occasionally, these vaccines caused vaccine virus-induced rabies cases. To elucidate the mechanisms of genetic selection and the effect of viral populations on these rabies cases, a next generation sequencing approach as well as comprehensive data analyses of the genetic diversity of Street Alabama Dufferin (SAD) and ERA vaccine virus strains and vaccine-induced rabies cases from Canada and several European countries were conducted. As a result, twelve newly generated sets of sequencing data from Canada and Poland were added to a pool of previously investigated samples. While the population-based analysis showed a segregation of viruses of ERA vaccine-induced rabies cases from those of SAD Bern original (SAD Bern(orig))-derived rabies cases, the in-depth variant analysis revealed three distinct combinations of selected variants for the ERA vaccine-induced cases, suggesting the presence of multiple replication-competent haplotypes in the investigated ERA-BHK21 vaccine. Our findings demonstrate the potential of a deep sequencing approach in combination with comprehensive analyses on the consensus, population, and variant level.
has issue date	2020-01-17(xsd:dateTime)
bibo:doi	10.3390/v12010115
bibo:pmid	31963517
has license	cc-by
sha1sum (hex)	549ecd5271e2f5d8e14450001ff82f7c6a0f084d
schema:url	https://doi.org/10.3390/v12010115
resource representing a document's title	Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns
has PubMed Central identifier	PMC7020022
has PubMed identifier	31963517
schema:publication	Viruses
resource representing a document's body	covid:549ecd5271e2f5d8e14450001ff82f7c6a0f084d#body_text
is schema:about of	named entity 'clusters' named entity 'based' named entity 'VACCINE' named entity 'PATTERNS' named entity 'SPECIFIC' named entity 'BASED' named entity 'DERIVED' named entity 'CLUSTERS' named entity 'POPULATION' named entity 'FILE' named entity 'PRODUCT' named entity 'VIRUSES' named entity 'GENOME' named entity 'UNIQUE' named entity 'CASES' named entity 'VARIANT' named entity 'RABIES' named entity 'cases' named entity 'vaccine' named entity 'rabies' named entity 'genome' named entity 'rabies vaccine' named entity '2.1' named entity '2.2' named entity 'amplicons' named entity 'Vaccine Strain' named entity 'genome' named entity 'viruses' named entity 'unique patterns' named entity 'demonstrate' named entity 'genome' named entity 'viruses' named entity 'Population' named entity 'specific'
is part of of	covid:549ecd5271e2f5d8e14450001ff82f7c6a0f084d#body_text Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns Rabies in wildlife has been successfully controlled in parts of Europe and North America using oral rabies vaccination, i.e., the distribution of baits containing live-attenuated virus strains. Occasionally, these vaccines caused vaccine virus-induced rabies cases. To elucidate the mechanisms of genetic selection and the effect of viral populations on these rabies cases, a next generation sequencing approach as well as comprehensive data analyses of the genetic diversity of Street Alabama Dufferin (SAD) and ERA vaccine virus strains and vaccine-induced rabies cases from Canada and several European countries were conducted. As a result, twelve newly generated sets of sequencing data from Canada and Poland were added to a pool of previously investigated samples. While the population-based analysis showed a segregation of viruses of ERA vaccine-induced rabies cases from those of SAD Bern original (SAD Bern(orig))-derived rabies cases, the in-depth variant analysis revealed three distinct combinations of selected variants for the ERA vaccine-induced cases, suggesting the presence of multiple replication-competent haplotypes in the investigated ERA-BHK21 vaccine. Our findings demonstrate the potential of a deep sequencing approach in combination with comprehensive analyses on the consensus, population, and variant level.

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