About: Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis
Creator	Liu, Jing Xiao, Xiaojuan Ye, Mao Wu, Ting Luo, Xuan Xia, Zanxian Deng, Meichun Jiang, Liping Kang, Shuntong Zuo, Zhihong
Source	Medline; PMC
abstract	This study aimed to provide systematic evidence for the association between multiorgan dysfunction and COVID-19 development. Several online databases were searched for articles published until May 13, 2020. Two investigators independently selected trials, extracted data, and evaluated the quality of individual trials. Single-arm meta-analysis was performed to summarize the clinical features of confirmed COVID-19 patients. Fixed effects meta-analysis was performed for clinically relevant parameters that were closely related to the patients’ various organ functions. A total of 73 studies, including 171,108 patients, were included in this analysis. The overall incidence of severe COVID-19 and mortality were 24% (95% confidence interval [CI], 20%-28%) and 2% (95% CI, 1%-3%), respectively. Patients with hypertension (odds ratio [OR] = 2.40; 95% CI, 2.08-2.78), cardiovascular disease (CVD) (OR = 3.54; 95% CI, 2.68-4.68), chronic obstructive pulmonary disease (COPD) (OR=3.70; 95% CI, 2.93-4.68), chronic liver disease (CLD) (OR=1.48; 95% CI, 1.09-2.01), chronic kidney disease (CKD) (OR = 1.84; 95% CI, 1.47-2.30), chronic cerebrovascular diseases (OR = 2.53; 95% CI, 1.84-3.49) and chronic gastrointestinal (GI) disease (OR = 2.13; 95% CI, 1.12-4.05) were more likely to develop severe COVID-19. Increased levels of lactate dehydrogenase (LDH), creatine kinase (CK), high-sensitivity cardiac troponin I (hs-cTnI), myoglobin, creatinine, urea, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin were highly associated with severe COVID-19. The incidence of acute organ injuries, including acute cardiac injury (ACI); (OR = 11.87; 95% CI, 7.64-18.46), acute kidney injury (AKI); (OR=10.25; 95% CI, 7.60-13.84), acute respiratory distress syndrome (ARDS); (OR=27.66; 95% CI, 18.58-41.18), and acute cerebrovascular diseases (OR=9.22; 95% CI, 1.61-52.72) was more common in patients with severe COVID-19 than in patients with non-severe COVID-19. Patients with a history of organ dysfunction are more susceptible to severe conditions. COVID-19 can aggravate an acute multiorgan injury.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.14336/ad.2020.0520
bibo:pmid	32765952
has license	cc-by
sha1sum (hex)	53780e6b0d1a4cdab5be5ff963d00aac2c47d0df
schema:url	https://doi.org/10.14336/ad.2020.0520
resource representing a document's title	Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis
has PubMed Central identifier	PMC7390520
has PubMed identifier	32765952
schema:publication	Aging Dis
resource representing a document's body	covid:53780e6b0d1a4cdab5be5ff963d00aac2c47d0df#body_text
is schema:about of	named entity 'severe' named entity 'CKD' named entity 'COVID-19' named entity '95% CI' named entity 'study' named entity 'provide' named entity 'HYPERTENSION' named entity 'CTNI' named entity 'HIGHLY' named entity 'SINGLE' named entity 'INJURY' named entity 'CREATININE' named entity 'INDIVIDUAL' named entity 'ASSOCIATION' named entity 'COVID-19' named entity '2.08' named entity 'EVALUATED' named entity 'INVESTIGATORS' named entity 'LIKELY' named entity 'ASSOCIATED WITH' named entity 'CLINICAL FEATURES' named entity 'DYSFUNCTION' named entity 'FIXED' named entity 'ONLINE' named entity 'HISTORY OF' named entity 'CREATINE KINASE' named entity '3D3' named entity 'GASTROINTESTINAL' named entity 'COMMON' named entity 'EVIDENCE FOR' named entity 'INCREASED' named entity 'CHRONIC KIDNEY DISEASE' named entity 'bilirubin' named entity '95% CI' named entity 'creatine kinase' named entity 'lactate dehydrogenase' named entity 'develop' named entity 'COVID-19' named entity 'highly' named entity '95% CI' named entity 'odds ratio' named entity 'patients' named entity 'online databases' named entity 'Fixed' named entity 'COVID-19' named entity 'acute' named entity 'chronic' named entity 'severe' named entity '95% CI' named entity 'hypertension' named entity 'myoglobin' named entity 'lactate dehydrogenase' named entity 'gastrointestinal' named entity '95% CI' named entity 'alanine aminotransferase' named entity '95% CI' named entity 'AST' named entity 'clinically relevant' named entity 'organ' named entity 'COPD' named entity 'AKI' named entity 'COVID-19' named entity '95% CI' named entity 'chronic liver disease' named entity '95% CI' named entity 'COVID-19' named entity 'cerebrovascular diseases' named entity 'COVID-19' named entity 'COVID-19' named entity 'creatinine' named entity 'acute kidney injury' named entity 'organ'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software