About: Spontaneous subcutaneous emphysema and pneumomediastinum in non-intubated patients with COVID-19

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About: Spontaneous subcutaneous emphysema and pneumomediastinum in non-intubated patients with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spontaneous subcutaneous emphysema and pneumomediastinum in non-intubated patients with COVID-19
Creator	Bernheim, Adam Chung, Michael Jacobi, Adam Gupta, Eber, Corey Cedillo, Mario Concepcion, Jose Finkelstein, Mark Gupta, Sean Libes, Richard Manna, Sayan Manna Bs, Sayan Maron, Samuel Steinberger, Sharon Toussie, Danielle Voutsinas, Nicholas Yogesh, Sean
Source	Elsevier; PMC
abstract	PURPOSE: We describe the presenting characteristics and hospital course of 11 novel coronavirus (COVID-19) patients who developed spontaneous subcutaneous emphysema (SE) with or without pneumomediastinum (SPM) in the absence of prior mechanical ventilation. MATERIALS AND METHODS: A total of 11 non-intubated COVID-19 patients (8 male and 3 female, median age 61 years) developed SE and SPM between March 15 and April 30, 2020 at a multi-center urban health system in New York City. Demographics (age, gender, smoking status, comorbid conditions, and body-mass index), clinical variables (temperature, oxygen saturation, and symptoms), and laboratory values (white blood cell count, C-reactive protein, D-dimer, and peak interleukin-6) were collected. Chest radiography (CXR) and computed tomography (CT) were analyzed for SE, SPM, and pneumothorax by a board-certified cardiothoracic-fellowship trained radiologist. RESULTS: Eleven non-intubated patients developed SE, 36% (4/11) of whom had SE on their initial CXR. Concomitant SPM was apparent in 91% (10/11) of patients, and 45% (5/11) also developed pneumothorax. Patients developed SE on average 13.3 days (SD: 6.3) following symptom onset. No patients reported a history of smoking. The most common comorbidities included hypertension (6/11), diabetes mellitus (5/11), asthma (3/11), dyslipidemia (3/11), and renal disease (2/11). Four (36%) patients expired during hospitalization. CONCLUSION: SE and SPM were observed in a cohort of 11 non-intubated COVID-19 patients without any known cause or history of invasive ventilation. Further investigation is required to elucidate the underlying mechanism in this patient population.
has issue date	2020-08-26(xsd:dateTime)
bibo:doi	10.1016/j.clinimag.2020.08.013
has license	no-cc
sha1sum (hex)	533813e75a014daab79a1f66e592c42195c7fefc
schema:url	https://doi.org/10.1016/j.clinimag.2020.08.013
resource representing a document's title	Spontaneous subcutaneous emphysema and pneumomediastinum in non-intubated patients with COVID-19
has PubMed Central identifier	PMC7448957
schema:publication	Clin Imaging
resource representing a document's body	covid:533813e75a014daab79a1f66e592c42195c7fefc#body_text
is schema:about of	named entity 'Short Title' named entity 'subcutaneous emphysema' named entity 'COVID' named entity 'Subcutaneous Air' named entity 'IL-6' named entity 'alveolar' named entity '4/11' named entity 'tested positive for COVID-19' named entity 'procalcitonin' named entity 'cough' named entity 'observer bias' named entity 'infection' named entity 'lung disease' named entity 'pneumothorax' named entity 'lung' named entity 'pneumocystis pneumonia' named entity 'pneumothoraces' named entity 'alveolar' named entity 'viral disease' named entity 'institutional review board' named entity 'PCP' named entity 'chest imaging' named entity 'radiographically' named entity 'radiographic' named entity 'Demographic' named entity 'pleural' named entity 'lungs' named entity 'pneumonia' named entity 'cytomegalovirus' named entity 'CXR' named entity 'radiographically' named entity 'soft tissues' named entity 'pneumothoraces' named entity 'vomiting' named entity 'sample size' named entity 'pneumomediastinum' named entity 'ferritin' named entity 'chest radiography' named entity 'comorbidities' named entity 'ceftriaxone' named entity 'mediastinum' named entity 'acute respiratory distress syndrome' named entity 'pneumomediastinum' named entity 'hemophagocytic lymphohistiocytosis' named entity 'pneumomediastinum' named entity 'CRP' named entity 'CRP' named entity 'air in the mediastinum' named entity 'irritants' named entity 'malaise' named entity 'comorbidities' named entity 'Barotrauma' named entity 'CXR' named entity 'LDH' named entity 'mechanical ventilation' named entity 'intravenous' named entity 'D-dimer' named entity 'alveolar pressure' named entity 'COVID' named entity 'radiographically' named entity 'intubated' named entity 'follow-up' named entity 'anteroposterior' named entity 'comorbid' named entity 'renal disease' named entity 'alveoli' named entity 'tachypneic'

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