About: Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus
Creator	Lo, Chia-Yun Cortese, Riccardo Colloca, Stefano Nicosia, Alfredo Ammendola, Virginia Pierantoni, Angiolo Vitelli, Alessandra Epstein, Suzanne Misplon, Julia Grabowska, Agnieszka Price, Graeme Quirion, Mary Soboleski, Mark
source	PMC
abstract	Among approximately 1000 adenoviruses from chimpanzees and bonobos studied recently, the Pan Adenovirus type 3 (PanAd3, isolated from a bonobo, Pan paniscus) has one of the best profiles for a vaccine vector, combining potent transgene immunogenicity with minimal pre-existing immunity in the human population. In this study, we inserted into a replication defective PanAd3 a transgene expressing a fusion protein of conserved influenza antigens nucleoprotein (NP) and matrix 1 (M1). We then studied antibody and T cell responses as well as protection from challenge infection in a mouse model. A single intranasal administration of PanAd3-NPM1 vaccine induced strong antibody and T cell responses, and protected against high dose lethal influenza virus challenge. Thus PanAd3 is a promising candidate vector for vaccines, including universal influenza vaccines.
has issue date	2013-03-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0055435
bibo:pmid	23536756
has license	cc0
sha1sum (hex)	532e417a66dbe4822a3f8f9b496c105ccc7dd412
schema:url	https://doi.org/10.1371/journal.pone.0055435
resource representing a document's title	Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus
has PubMed Central identifier	PMC3594242
has PubMed identifier	23536756
schema:publication	PLoS One
resource representing a document's body	covid:532e417a66dbe4822a3f8f9b496c105ccc7dd412#body_text
is schema:about of	named entity 'high' named entity 'immunogenicity' named entity 'isolated' named entity 'bonobos' named entity 'studied' covid:arg/532e417a66dbe4822a3f8f9b496c105ccc7dd412 named entity 'minimal' named entity 'matrix' named entity 'study' named entity 'Thus' named entity 'T cell' named entity 'influenza' named entity 'Adenovirus' named entity 'inserted' named entity 'intranasal administration' named entity 'infection' named entity 'influenza vaccines' named entity 'bonobos' named entity 'fusion protein' named entity 'vector' named entity 'Pan paniscus' named entity 'majority rule' named entity 'MHC-I' named entity 'antigens' named entity 'transfected' named entity 'antibodies' named entity 'mucosal' named entity 'adenovirus' named entity 'adenoviruses' named entity 'body weight' named entity 'bovine growth hormone' named entity 'Splenocytes' named entity 'San Jose' named entity 'viral DNA' named entity 'antibody' named entity 'alkaline phosphatase' named entity 'Center for Biologics Evaluation and Research' named entity 'PGK' named entity 'PBS' named entity 'highly conserved' named entity 'respiratory tract' named entity 'replication incompetent' named entity 'cloned' named entity 'antigens' named entity 'BALB/c' named entity 'expression vector' named entity 'CD8 +' named entity 'Glycerol' named entity 'vector' named entity 'immune response' named entity 'adenovirus' named entity 'anatomical' named entity 'adenovirus' named entity 'mice' named entity 'human cytomegalovirus' named entity 'vaccine' named entity 'Canada' named entity 'expression cassette' named entity 'RSV' named entity 'consensus sequences' named entity 'informed consent' named entity 'resistance gene' named entity 'Association for Assessment and Accreditation of Laboratory Animal Care International' named entity 'IgG' named entity 'virus' named entity 'lung tissue' named entity 'IgG antibodies' named entity 'adenovirus' named entity 'intramuscular'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software