About: Underdiagnoses of Rickettsia in patients hospitalized with acute fever in Indonesia: observational study results

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About: Underdiagnoses of Rickettsia in patients hospitalized with acute fever in Indonesia: observational study results Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Underdiagnoses of Rickettsia in patients hospitalized with acute fever in Indonesia: observational study results
Creator	Sudarmono, Pratiwi Lau, Chuen-Yen Alisjahbana, Bachti Asdie, Rizka Gasem, Muhammad Hadi, Usman Karyana, Muhammad Kosasih, Herman Laras, Kanti Liang, C Lokida, Dewi Lukman, Nurhayati Made, I Mubin, Risna Murniati, Dewi Rusli, Musofa Utama, Susila
Source	PMC
abstract	BACKGROUND: Reports of human rickettsial infection in Indonesia are limited. This study sought to characterize the epidemiology of human rickettsioses amongst patients hospitalized with fever at 8 tertiary hospitals in Indonesia. METHODS: Acute and convalescent blood from 975 hospitalized non-dengue patients was tested for Rickettsia IgM and IgG by ELISA. Specimens from cases with seroconversion or increasing IgM and/or IgG titers were tested for Rickettsia IgM and IgG by IFA and Rickettsia genomes using primers for Rickettsia (R.) sp, R. typhi, and Orientia tsutsugamushi. Testing was performed retrospectively on stored specimens; results did not inform patient management. RESULTS: R. typhi, R. rickettsii, and O. tsutsugamushi IgG antibodies were identified in 269/872 (30.8%), 36/634 (5.7%), and 19/504 (3.8%) of samples, respectively. For the 103/975 (10.6%) non-dengue patients diagnosed with acute rickettsial infection, presenting symptoms included nausea (72%), headache (69%), vomiting (43%), lethargy (33%), anorexia (32%), arthralgia (30%), myalgia (28%), chills (28%), epigastric pain (28%), and rash (17%). No acute rickettsioses cases were suspected during hospitalization. Discharge diagnoses included typhoid fever (44), dengue fever (20), respiratory infections (7), leptospirosis (6), unknown fever (6), sepsis (5), hepatobiliary infections (3), UTI (3), and others (9). Fatalities occurred in 7 (6.8%) patients, mostly with co-morbidities. CONCLUSIONS: Rickettsial infections are consistently misdiagnosed, often as leptospirosis, dengue, or Salmonella typhi infection. Clinicians should include rickettsioses in their differential diagnosis of fever to guide empiric management; laboratories should support evaluation for rickettsial etiologies; and public policy should be implemented to reduce burden of disease.
has issue date	2020-05-24(xsd:dateTime)
bibo:doi	10.1186/s12879-020-05057-9
has license	cc-by
sha1sum (hex)	52871b8db269825cab7864ac767b561798f2f363
schema:url	https://doi.org/10.1186/s12879-020-05057-9
resource representing a document's title	Underdiagnoses of Rickettsia in patients hospitalized with acute fever in Indonesia: observational study results
has PubMed Central identifier	PMC7245627
schema:publication	BMC Infect Dis
resource representing a document's body	covid:52871b8db269825cab7864ac767b561798f2f363#body_text
is schema:about of	named entity 'titers' named entity 'rickettsial' named entity 'laboratories' named entity 'blood' named entity 'presenting' named entity 'identified' named entity 'typhoid fever' named entity 'rickettsial' named entity 'UTI' named entity 'study' named entity 'myalgia' named entity 'observational study' named entity 'LETHARGY' named entity 'DISCHARGE' named entity 'BACKGROUND' named entity 'LABORATORIES' named entity '283' named entity 'GENOMES' named entity 'THEIR' named entity 'INFORM' named entity 'EMPIRIC' named entity 'TYPHI' named entity 'TESTED FOR' named entity 'FEVER' named entity 'TO REDUCE' named entity 'SUPPORT' named entity 'IDENTIFIED' named entity 'EPIDEMIOLOGY' named entity 'ACUTE' named entity 'patients' named entity 'evaluation' named entity 'nausea' named entity 'Results' named entity 'disease' named entity 'management' named entity 'IFA' named entity 'inform' named entity 'infections' named entity 'fever' named entity 'sepsis' named entity 'Indonesia' named entity 'This' named entity 'hospitals' named entity 'samples' named entity 'etiologies' named entity 'support' named entity 'seroconversion' named entity 'rash' named entity 'sepsis' named entity 'empiric' named entity 'rickettsioses' named entity 'Rickettsia' named entity 'chills' named entity 'dengue' named entity '5.7%' named entity 'Rickettsial' named entity 'Salmonella typhi' named entity 'fever' named entity 'fever' named entity 'dengue' named entity 'differential diagnosis' named entity 'observational study' named entity 'case report' named entity 'IgM' named entity 'epidemiology' named entity 'infection' named entity 'Rickettsia'

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