About: Burst-suppression (BS) is a reliable electroencephalogram (EEG) indicator of excessive deep anesthesia common in mammals. Since some intermittent events are known to follow a power-law, we investigated the power-law hypothesis in BS by comparing it with alternative functions focusing on flattish periods and developed a new method for detecting BS as an application of statistical model in dogs. Young-adult 6 beagles and senior 6 beagles were anesthetized with sevoflurane 2.0%-5.0% and three of 64 sec EEG (256 Hz) from Fpz-T4 via scalp electrodes were recorded. Three thresholds for peak-to-peak voltage were set: mean value of peak-to-peak voltage at sevoflurane 2.0% in each dog (AS2%), 3mcrV, and 5mcrV. The subthreshold periods were discriminated as $/tau$ events. We fitted the empirical probability distribution of $/tau$ by a power-law distribution and an exponential distribution. These two distributions were compared by the normalized log-likelihood ratio test to see which distribution was better fit. At sevoflurane 2.0%-3.0%, by any threshold, the exponential distribution became better fit in all dogs. The power-law distribution became better fit only when BS expressed on EEG. No strict threshold was required for detection of onset of BS. We showed a transition from exponential behavior to power-law behavior on the right tail of $/tau$ distributions in response to the appearance of suppression waves with increasing anesthetic. This will be a robust tool for BS detection.   Goto Sponge  NotDistinct  Permalink

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  • Burst-suppression (BS) is a reliable electroencephalogram (EEG) indicator of excessive deep anesthesia common in mammals. Since some intermittent events are known to follow a power-law, we investigated the power-law hypothesis in BS by comparing it with alternative functions focusing on flattish periods and developed a new method for detecting BS as an application of statistical model in dogs. Young-adult 6 beagles and senior 6 beagles were anesthetized with sevoflurane 2.0%-5.0% and three of 64 sec EEG (256 Hz) from Fpz-T4 via scalp electrodes were recorded. Three thresholds for peak-to-peak voltage were set: mean value of peak-to-peak voltage at sevoflurane 2.0% in each dog (AS2%), 3mcrV, and 5mcrV. The subthreshold periods were discriminated as $/tau$ events. We fitted the empirical probability distribution of $/tau$ by a power-law distribution and an exponential distribution. These two distributions were compared by the normalized log-likelihood ratio test to see which distribution was better fit. At sevoflurane 2.0%-3.0%, by any threshold, the exponential distribution became better fit in all dogs. The power-law distribution became better fit only when BS expressed on EEG. No strict threshold was required for detection of onset of BS. We showed a transition from exponential behavior to power-law behavior on the right tail of $/tau$ distributions in response to the appearance of suppression waves with increasing anesthetic. This will be a robust tool for BS detection.
subject
  • Anesthesia
  • Anesthesiology
  • Electrophysiology
  • Emerging technologies
  • Neurophysiology
  • Exponentials
  • Mathematics in medicine
  • Statistical theory
  • Power laws
  • Statistical laws
  • Theory of probability distributions
  • Psychiatric assessment
  • Brain–computer interfacing
  • Electrodiagnosis
  • Electroencephalography
  • Neurotechnology
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