About: Changes in Cytokine Levels and NK Cell Activation Associated with Influenza

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Changes in Cytokine Levels and NK Cell Activation Associated with Influenza
Creator	Altfeld, Marcus Jost, Stephanie Peterson, Eric Quillay, Heloise Reardon, Jeff Binder, William Bryant, Nancy Parry, Blair Simmons, Rachel
Source	Medline; PMC
abstract	Several studies have highlighted the important role played by murine natural killer (NK) cells in the control of influenza infection. However, human NK cell responses in acute influenza infection, including infection with the 2009 pandemic H1N1 influenza virus, are poorly documented. Here, we examined changes in NK cell phenotype and function and plasma cytokine levels associated with influenza infection and vaccination. We show that absolute numbers of peripheral blood NK cells, and particularly those of CD56(bright) NK cells, decreased upon acute influenza infection while this NK cell subset expanded following intramuscular influenza vaccination. NK cells exposed to influenza antigens were activated, with higher proportions of NK cells expressing CD69 in study subjects infected with seasonal influenza strains. Vaccination led to increased levels of CD25+ NK cells, and notably CD56(bright) CD25+ NK cells, whereas decreased amounts of this subset were present in the peripheral blood of influenza infected individuals, and predominantly in study subjects infected with the 2009 pandemic H1N1 influenza virus. Finally, acute influenza infection was associated with low plasma concentrations of inflammatory cytokines, including IFN-γ, MIP-1β, IL-2 and IL-15, and high levels of the anti-inflammatory cytokines IL-10 and IL-1ra. Altogether, these data suggest a role for the CD56(bright) NK cell subset in the response to influenza, potentially involving their recruitment to infected tissues and a local production and/or uptake of inflammatory cytokines.
has issue date	2011-09-23(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0025060
bibo:pmid	21966414
has license	cc-by
sha1sum (hex)	52659b7eb39ce3c761658f1f3e5df475cf495919
schema:url	https://doi.org/10.1371/journal.pone.0025060
resource representing a document's title	Changes in Cytokine Levels and NK Cell Activation Associated with Influenza
has PubMed Central identifier	PMC3179484
has PubMed identifier	21966414
schema:publication	PLoS One
resource representing a document's body	covid:52659b7eb39ce3c761658f1f3e5df475cf495919#body_text
is schema:about of	named entity 'influenza' named entity 'peripheral blood' named entity 'responses' named entity 'H1N1' named entity 'proportions' named entity 'levels' named entity 'NK Cell' covid:arg/52659b7eb39ce3c761658f1f3e5df475cf495919 named entity 'influenza' named entity 'CD56' named entity 'cytokines' named entity 'strains' named entity 'NK cell' named entity 'infected' named entity 'plasma' named entity 'influenza' named entity 'high' named entity 'CD56' named entity 'natural killer (NK) cells' named entity 'IL-15' named entity 'infection' named entity 'documented' named entity 'infection' named entity 'virus' named entity 'infection' named entity 'involving' named entity 'CD69' named entity 'levels' named entity 'plasma' named entity 'influenza' named entity 'NK cell' named entity 'NK cells' named entity 'inflammatory cytokines' named entity 'plasma' named entity 'CD56' named entity 'influenza infection' named entity 'IL-15' named entity 'antigens' named entity 'NK cell' named entity 'phenotype' named entity 'NK cells' named entity 'cytokine' named entity 'Influenza' named entity 'NK Cell' named entity 'Cytokine' named entity 'Cytokines' named entity 'K562' named entity 'influenza infection' named entity 'influenza vaccines' named entity 'FlowJo' named entity 'incubation' named entity 'CD56' named entity 'cytokines' named entity 'plasma levels' named entity 'influenza virus' named entity 'intramuscular' named entity '3, 4' named entity 'lower respiratory tract' named entity 'NK cell' named entity 'influenza' named entity 'NK cell' named entity 'NK cells' named entity 'H1N1' named entity 'Apoptosis' named entity 'infection' named entity 'viruses' named entity 'major histocompatibility complex' named entity 'influenza infection' named entity 'viruses' named entity 'CD56' named entity 'cell death' named entity 'non-parametric' named entity 'influenza hemagglutinin'

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