About: Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses

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About: Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses
Creator	Abraham, J Lu, J Radoshitzky, S Cg, Albariñ Kwong, J
topic	covid:5229e54b1866448ee22e138bb7c12ab67547ccac#this
Source	Medline; PMC
abstract	The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever. Amapari (AMAV) and Tacaribe (TCRV), two nonpathogenic NW clade B arenaviruses that do not use human TfR1, are closely related to the NW arenaviruses that cause hemorrhagic fevers. Here we show that pseudotyped viruses bearing the surface glycoprotein (GP) of AMAV or TCRV can infect cells using the TfR1 orthologs of several mammalian species, including those of their respective natural hosts, the small rodent Neacomys spinosus and the fruit bat Artibeus jamaicensis. Mutation of one residue in human TfR1 makes it a functional receptor for TCRV, and mutation of four residues makes it a functional receptor for AMAV. Our data support an in vivo role for TfR1 in the replication of most, if not all, NW clade B arenaviruses, and suggest that with modest changes in their GPs the nonpathogenic arenaviruses could use human TfR1 and emerge as human pathogens.
has issue date	2009-04-03(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1000358
bibo:pmid	19343214
has license	cc0
sha1sum (hex)	5229e54b1866448ee22e138bb7c12ab67547ccac
schema:url	https://doi.org/10.1371/journal.ppat.1000358
resource representing a document's title	Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses
has PubMed Central identifier	PMC2658809
has PubMed identifier	19343214
schema:publication	PLoS Pathog
resource representing a document's body	covid:5229e54b1866448ee22e138bb7c12ab67547ccac#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/5229e54b1866448ee22e138bb7c12ab67547ccac
is schema:about of	named entity 'RECEPTORS' named entity 'mammalian species' named entity 'human' named entity 'Cellular' named entity 'ARENAVIRUS' named entity 'ARENAVIRUSES' named entity 'ROLE' named entity 'MODEST' named entity 'NEW' named entity 'CAUSE' named entity 'HEMORRHAGIC FEVERS' named entity 'WORLD' named entity 'DO NOT USE' named entity 'RECEPTOR' named entity 'RELATED' named entity 'USE' named entity 'ENTER' named entity 'DATA' named entity 'CLADE' named entity 'GPS' named entity 'ABILITY' named entity 'OUR' named entity 'REPLICATION' named entity 'MAMMALIAN' named entity 'EMERGE' named entity 'RODENT' named entity 'ARTIBEUS JAMAICENSIS' named entity 'SUPPORT' named entity 'SPECIES' named entity 'PATHOGENS' named entity 'FUNCTIONAL' named entity 'HEMORRHAGIC FEVER' named entity 'VIRUSES' named entity 'MUTATION' named entity 'HUMAN' named entity 'NEW' named entity 'AMAV' named entity 'RESIDUE' named entity 'IN VIVO' named entity 'CHANGES' named entity 'NATURAL' named entity 'CELLS' named entity 'HOSTS' named entity 'FRUIT' named entity 'TFR1' named entity 'CELLULAR' named entity 'TRANSFERRIN RECEPTOR 1' named entity 'WORLD' named entity 'ARENAVIRUSES' named entity 'SUGGEST' named entity 'BAT' named entity 'THEIR' named entity 'BEARING' named entity 'TRANSFERRIN RECEPTOR 1' named entity 'INCLUDING' named entity 'SPECIES' named entity 'HERE' named entity 'NEACOMYS SPINOSUS' named entity 'USING' named entity 'CLADE' named entity 'HOST' named entity 'TCRV' named entity 'ITS' named entity 'INFECT' named entity 'SMALL' named entity 'modest' named entity 'respective' named entity 'clade' named entity 'New World' named entity 'Orthologs' named entity 'hemorrhagic fevers' named entity 'clade' named entity 'hemorrhagic fever' named entity 'receptor' named entity 'pseudotyped viruses'

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