About: Presumptive Development of Fibrotic Lung Disease From Bordetella bronchiseptica and Post-infectious Bronchiolitis Obliterans in a Dog

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About: Presumptive Development of Fibrotic Lung Disease From Bordetella bronchiseptica and Post-infectious Bronchiolitis Obliterans in a Dog Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Presumptive Development of Fibrotic Lung Disease From Bordetella bronchiseptica and Post-infectious Bronchiolitis Obliterans in a Dog
Creator	Harmon, Mark Masseau, Isabelle Reinero, Carol Williams, Kurt Sharp, Claire Jaffey, Jared Rozanski, Elizabeth Schermerhorn, Thomas
source	Medline; PMC
abstract	A 7-month-old Miniature Poodle acquired from a pet store developed cough and subsequently respiratory distress compatible with Bordetella bronchiseptica infection. Partial but incomplete resolution of clinical signs and thoracic radiographic/computed tomographic imaging lesions were noted with use of susceptibility-guided antimicrobials. Additionally, a concern for an infectious nidus led to left cranial lung lobectomy at 9 months of age. Histopathology predominantly revealed polypoid and constrictive bronchiolitis obliterans (i.e., small airway disease). Intermittent antimicrobial administration over the next 5 years failed to blunt progressive clinical signs. At 8 years, necropsy confirmed severe airway-centered interstitial fibrosis. This pattern of fibrosis was strongly suggestive of underlying small airway disease as the trigger. In retrospect, post-infectious bronchiolitis obliterans (PIBO), a syndrome in young children caused by pulmonary infections but not yet recognized in pet dogs, likely initiated a pathway of fibrosis in this dog. In dogs with risk factors for community-acquired pathogens such as Bordetella bronchiseptica, PIBO is a differential diagnosis with development of severe, persistent respiratory signs incompletely responsive to appropriate antimicrobials. Untreated PIBO may lead to airway-centered interstitial fibrosis. Future study is required to determine if targeted therapy of PIBO could alter the course of end-stage pulmonary fibrosis.
has issue date	2019-10-10(xsd:dateTime)
bibo:doi	10.3389/fvets.2019.00352
bibo:pmid	31649945
has license	cc-by
sha1sum (hex)	52075e1e28bc2952fb7a2360fae88c76b36c722a
schema:url	https://doi.org/10.3389/fvets.2019.00352
resource representing a document's title	Presumptive Development of Fibrotic Lung Disease From Bordetella bronchiseptica and Post-infectious Bronchiolitis Obliterans in a Dog
has PubMed Central identifier	PMC6795681
has PubMed identifier	31649945
schema:publication	Front Vet Sci
resource representing a document's body	covid:52075e1e28bc2952fb7a2360fae88c76b36c722a#body_text
is schema:about of	named entity 'POST' named entity 'LUNG DISEASE' named entity 'INFECTIOUS BRONCHIOLITIS' named entity 'BRONCHIOLITIS OBLITERANS' named entity 'FIBROTIC' named entity 'DEVELOPMENT' named entity 'PRESUMPTIVE' named entity 'BORDETELLA BRONCHISEPTICA' named entity 'DOG' named entity 'Dog' named entity 'Bordetella bronchiseptica' named entity 'pet store' named entity 'Physical examination findings' named entity 'small airways' named entity 'tracheobronchitis' named entity 'biopsy' named entity 'dog' named entity 'susceptibility testing' named entity 'euthanasia' named entity 'Pulmonary fibrosis' named entity 'Thoracic' named entity 'Frontiers in Veterinary Science' named entity 'real-time PCR' named entity 'thoracic' named entity 'interstitial fibrosis' named entity 'cough' named entity 'Bordetella' named entity 'endotracheal tube' named entity 'pharyngeal' named entity 'interstitium' named entity 'alveolar' named entity 'high resolution CT' named entity 'sternal' named entity 'auscultation' named entity 'nebulization' named entity 'q24' named entity 'respiration' named entity 'companion animals' named entity 'traction bronchiectasis' named entity 'histologic' named entity 'clinical signs' named entity 'Chronic bronchitis' named entity 'crackles' named entity 'Physical examination findings' named entity 'hematopoietic cell' named entity 'auscultation' named entity 'endotracheal tube' named entity 'dog' named entity 'University of Missouri' named entity 'bacterial pathogen' named entity 'Bordetella bronchiseptica' named entity 'sequela' named entity 'idiopathic pulmonary fibrosis' named entity 'pimobendan' named entity 'radiographic' named entity 'Thoracic' named entity 'tricuspid regurgitation' named entity 'fibrosis' named entity 'corticosteroids' named entity 'dyspnea' named entity 'parenchyma' named entity 'lung lobes' named entity 'PCR' named entity 'respiratory rate' named entity 'antimicrobials' named entity 'Bordetella pertussis' named entity 'ventricle' named entity 'mechanically ventilated' named entity 'community-acquired pneumonia' named entity 'dog' named entity 'dog' named entity 'dog' named entity 'bronchoscopy' named entity 'respiratory distress'

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