About: Dynamics of coagulopathy in patients with different COVID-19 severity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dynamics of coagulopathy in patients with different COVID-19 severity
Creator	Margolis, Leonid Ataullakhanov, Fazly Dukhin, Oleg Elizarova, Antonina Glebova, Ksenia Kalinskaya, Anna Maltseva, Alexandra Mazus, Alexey Molodtsov, Ivan Nikonov, Evgeniy Sapozhnikova, Olga Shakhidzhanov, Soslan Shpektor, Alexander Sokorev, Denis Spiridonov, Ilia Stonogina, Daria Vasilieva, Elena
Source	MedRxiv; Medline; PMC
abstract	With the progress of COVID-19 studies, it became evident that SARS-CoV-2 infection is often associated with thrombotic complications. The goal of our present study was to evaluate which component of clot formation process including endothelial function, platelets aggregation and plasma coagulation, as well as endogenous fibrinolysis in patients with COVID-19 correlates with the severity of the disease. We prospectively included 58 patients with COVID-19 and 47 healthy volunteers as a control group that we recruited before the pandemic started. It turns out that plasma coagulation with subsequent platelet aggregation, but not endothelial function, correlates with the severity of the COVID-19. IL-6 blockade may play a beneficial role in COVID-19 induced coagulopathy.
has issue date	2020-07-04(xsd:dateTime)
bibo:doi	10.1101/2020.07.02.20145284
bibo:pmid	32637973
has license	no-cc
sha1sum (hex)	5206bc4b00611150b88f7e8bdb766e95638867c6
schema:url	https://doi.org/10.1101/2020.07.02.20145284
resource representing a document's title	Dynamics of coagulopathy in patients with different COVID-19 severity
has PubMed Central identifier	PMC7340199
has PubMed identifier	32637973
schema:publication	medRxiv
resource representing a document's body	covid:5206bc4b00611150b88f7e8bdb766e95638867c6#body_text
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