About: Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication

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About: Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins
Creator	Dimitrova-Shumkovska, Jasmina Krstanoski, Ljupcho Veenman, Leo
Source	Medline; PMC
abstract	Increased interest in natural antioxidants has brought to light the fucoidans (sulfated polysaccharides present in brown marine algae) as highly valued nutrients as well as effective and safe therapeutics against several diseases. Based on their satisfactory in vitro antioxidant potency, researchers have identified this molecule as an efficient remedy for neuropathological as well as metabolic disorders. Some of this therapeutic activity is accomplished by upregulation of cytoprotective molecular pathways capable of restoring the enzymatic antioxidant activity and normal mitochondrial functions. Sirtuin-3 has been discovered as a key player for achieving the neuroprotective role of fucoidan by managing these pathways, whose ultimate goal is retrieving the entirety of the antioxidant response and preventing apoptosis of neurons, thereby averting neurodegeneration and brain injuries. Another pathway whereby fucoidan exerts neuroprotective capabilities is by interactions with P-selectin on endothelial cells, thereby preventing macrophages from entering the brain proper. Furthermore, beneficial influences of fucoidan have been established in hepatocytes after xenobiotic induced liver injury by decreasing transaminase leakage and autophagy as well as obtaining optimal levels of intracellular fiber, which ultimately prevents fibrosis. The hepatoprotective role of this marine polysaccharide also includes a sirtuin, namely sirtuin-1 overexpression, which alleviates obesity and insulin resistance through suppression of hyperglycemia, reducing inflammation and stimulation of enzymatic antioxidant response. While fucoidan is very effective in animal models for brain injury and neuronal degeneration, in general, it is accepted that fucoidan shows somewhat limited potency in liver. Thus far, it has been used in large doses for treatment of acute liver injuries. Thus, it appears that further optimization of fucoidan derivatives may establish enhanced versatility for treatments of various disorders, in addition to brain injury and disease.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.3390/md18050242
bibo:pmid	32380741
has license	cc-by
sha1sum (hex)	51f55376db12418975d36077e40fbf18bfb37baf
schema:url	https://doi.org/10.3390/md18050242
resource representing a document's title	Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins
has PubMed Central identifier	PMC7281157
has PubMed identifier	32380741
schema:publication	Mar Drugs
resource representing a document's body	covid:51f55376db12418975d36077e40fbf18bfb37baf#body_text
is schema:about of	named entity 'insulin resistance' named entity 'autophagy' named entity 'preventing' named entity 'mitochondrial' named entity 'brain injury' named entity 'marine algae' named entity 'fucoidan' named entity 'sirtuin' named entity 'researchers' named entity 'Liver' named entity 'PATHWAY' named entity 'HIGHLY' named entity 'OPTIMIZATION' named entity 'RETRIEVING' named entity 'NEUROPROTECTIVE' named entity 'BRAIN INJURIES' named entity 'SIRTUIN' named entity 'METABOLIC DISORDERS' named entity 'INJURIES' named entity 'INFLAMMATION' named entity 'UPREGULATION' named entity 'TREATMENT' named entity 'VARIOUS' named entity 'LIGHT' named entity 'INTEREST' named entity 'ENZYMATIC' named entity 'MITOCHONDRIAL' named entity 'KEY' named entity 'MARINE ALGAE' named entity 'AUTOPHAGY' named entity 'PROPER' named entity 'PRESENT' named entity 'ultimately' named entity 'levels' named entity 'fucoidan' named entity 'therapeutics' named entity 'response' named entity 'injuries' named entity 'antioxidant' named entity 'xenobiotic' named entity 'ultimate' named entity 'Some' named entity 'effective' named entity 'hepatocytes' named entity 'liver' named entity 'brain injuries' named entity 'potency' named entity 'fucoidan' named entity 'upregulation' named entity 'neuroprotective' named entity 'molecule' named entity 'obesity' named entity 'inflammation' named entity 'sirtuin' named entity 'P-selectin' named entity 'sulfated' named entity 'neuropathological' named entity 'transaminase' named entity 'neuronal degeneration' named entity 'polysaccharide' named entity 'neurodegeneration' named entity 'Liver' named entity 'Fucoidan' named entity 'HSV1' named entity 'IL-8' named entity 'TBI' named entity 'glucose transporter' named entity 'extravascular space' named entity 'SIRT3' named entity 'SIRT1' named entity 'endothelium' named entity 'NK cells' named entity 'GSH' named entity 'ssRNA' named entity 'dose-dependent manner' named entity 'hemoglobin' named entity 'neurodegenerative diseases' named entity 'SIRT1' named entity 'methyl'

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