About: Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis
Creator	Alho, Olli-Pekka Autio, Timo Koivunen, Petri Koskenkorva, Timo Leino, Tuomo
source	Medline; PMC
abstract	OBJECTIVE: To illuminate the pathophysiology of acute rhinosinusitis (ARS) with sequential monitoring of inflammatory biomarkers during an ARS episode and to clarify their diagnostic usability in bacterial ARS. STUDY DESIGN: Inception cohort study with 50 conscripts with ARS. METHODS: We collected peripheral blood high‐sensitive C‐reactive protein (hs‐CRP), white blood cell (WBC), procalcitonin, and nasal nitric oxide (nNO) counts at 2 to 3 and 9 to 10 days of symptoms during an ARS episode. We simultaneously gathered various clinical parameters and microbiological samples. Bacterial ARS was confirmed with a positive culture of sinus aspirate. RESULTS: Reciprocal correlations and a significant change in biomarker levels between the two visits suggest that ARS involves a local and systemic inflammatory response that was strongest at 2 to 3 days. High‐sensitive CRP and nNO reflected responses best (52% had increased CRP levels at 2–3 days; 66% had decreased nNO levels). White blood cell and procalcitonin counts rarely exceeded the reference range. Increased local and systemic inflammatory response were linked to multiple, adenoviral, or influenza A viral etiology or the detection of bacterial ARS. Local response correlated with imaging findings of wide paranasal sinus involvement and ostiomeatal complex occlusion. At 9 to 10 days, elevated (≥ 11 mg/L) and moderately elevated (≥ 49 mg/L) hs‐CRP predicted bacterial ARS well (likelihood ratio [LR]+ 3.3 and LR+ 15.8, respectively), but the sensitivity for both findings remained low. CONCLUSION: Acute rhinosinusitis (particularly bacterial ARS) involves a local and systemic inflammatory response that is strongest at the beginning of symptoms. Elevated hs‐CRP supports the diagnosis of bacterial ARS. LEVEL OF EVIDENCE: 4. Laryngoscope, 2016 127:E55–E61, 2017
has issue date	2016-10-18(xsd:dateTime)
bibo:doi	10.1002/lary.26344
bibo:pmid	27753120
has license	no-cc
sha1sum (hex)	51e5487e7da1989ecf0dcf61fb5d95ff0ce14ed5
schema:url	https://doi.org/10.1002/lary.26344
resource representing a document's title	Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis
has PubMed Central identifier	PMC7165676
has PubMed identifier	27753120
schema:publication	Laryngoscope
resource representing a document's body	covid:51e5487e7da1989ecf0dcf61fb5d95ff0ce14ed5#body_text
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