About: Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model

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About: Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model
Creator	Barlow, John Miller, Peter Campbell, Mary Klopfer, Connor Stebbins, Erin Griggs, David Huston, Christopher Jumani, Rajiv Meyers, Marvin
source	Medline; PMC
abstract	Cryptosporidiosis causes life-threatening diarrhea in infants, but the best available treatment is only modestly efficacious. Rodents infected with relevant Cryptosporidium species do not develop diarrhea, which complicates drug development. Cryptosporidium parvum infection of dairy calves, however, causes an illness like that seen in infants. Here, the clinical and microbiologic anti-Cryptosporidium efficacy of the piperazine-based compound MMV665917 was demonstrated in neonatal calves. Oral administration of MMV665917 (22 mg/kg once daily) was begun two days after the onset of severe diarrhea and continued for seven days. Treatment resulted in prompt resolution of diarrhea, and reduced total fecal oocyst shedding by ~94%. MMV665917 was useful for treatment, rather than just prophylaxis, since it was safe and effective when administered well after the onset of diarrhea. Furthermore, even though all animals received intensive supportive care, there was a strong trend towards improved secondary health outcomes, including general health, appetite, and dehydration measures amongst treated animals. These data establish MMV665917 as an outstanding lead compound for Cryptosporidium drug development.
has issue date	2018-01-08(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0006183
bibo:pmid	29309415
has license	cc-by
sha1sum (hex)	51dd0bdd5680a978bf834d5b4cbfaa8dd84dea90
schema:url	https://doi.org/10.1371/journal.pntd.0006183
resource representing a document's title	Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model
has PubMed Central identifier	PMC5774826
has PubMed identifier	29309415
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:51dd0bdd5680a978bf834d5b4cbfaa8dd84dea90#body_text
is schema:about of	named entity 'PIPERAZINE' named entity 'EFFICACY' named entity 'DRUG' named entity 'infants' named entity 'develop' named entity 'Here' named entity 'strong' named entity 'animals' named entity 'treated' named entity 'dairy' named entity 'calf' named entity 'EFFECTIVE' named entity 'DAIRY CALVES' named entity 'GENERAL HEALTH' named entity 'HERE' named entity 'SEVERE DIARRHEA' named entity 'IMPROVED' named entity 'EFFICACY' named entity 'BASED' named entity 'DRUG DEVELOPMENT' named entity 'CONTINUED' named entity 'USEFUL' named entity 'FECAL' named entity 'INFECTION' named entity 'MEASURES' named entity 'PROMPT' named entity 'SAFE' named entity 'ANIMALS' named entity 'TREND' named entity 'CRYPTOSPORIDIOSIS' named entity 'ILLNESS' named entity 'STRONG' named entity 'ADMINISTERED' named entity 'TOTAL' named entity 'COMPOUND' named entity 'CRYPTOSPORIDIUM SPECIES' named entity 'ONSET OF' named entity 'BASED' named entity 'CLINICAL' named entity 'INFECTED' named entity 'CRYPTOSPORIDIUM PARVUM' named entity 'LEAD' named entity 'CRYPTOSPORIDIOSIS' named entity 'DAIRY CALF' named entity 'JUST' named entity 'DAYS' named entity 'SECONDARY' named entity 'SEVEN' named entity 'BEST' named entity 'SUPPORTIVE CARE' named entity 'SEEN' named entity 'RECEIVED' named entity 'RELEVANT' named entity 'PIPERAZINE' named entity 'APPETITE' named entity 'INCLUDING' named entity 'DATA' named entity 'CRYPTOSPORIDIUM' named entity 'OOCYST' named entity 'CALVES' named entity 'RATHER' named entity 'THESE' named entity 'DIARRHEA' named entity 'AVAILABLE TREATMENT' named entity 'ORAL ADMINISTRATION' named entity 'REDUCED' named entity 'HEALTH OUTCOMES' named entity 'DEHYDRATION' named entity 'LIKE' named entity 'OUTSTANDING' named entity 'LEAD COMPOUND' named entity 'WAS A' named entity 'PROPHYLAXIS'

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