About: Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective
Creator	Augusseau-Rivière, Brigitte Bosson, Jean-Luc Couturier, Pascal Gavazzi, Gaëtan Mallaret, Marie-Reine Seynaeve, Damien Morel-Baccard Pharmd, Christine Pharmd, Caroline
Source	Elsevier; Medline; PMC
abstract	OBJECTIVES: To describe a human metapneumovirus (hMPV) outbreak occurring in a nursing home for older adults and to identify the risk factors associated with the clinical infection. DESIGN: A retrospective, case-controlled study. SETTING AND PARTICIPANTS: A French nursing home for older adults between December 27, 2014 and January 20, 2015. Probable cases were residents presenting at least 1 respiratory symptom or 1 constitutional symptom. Confirmed cases identified in the same way as probable cases but with a positive RT-PCR test for hMPV. Controls were residents with no symptoms of respiratory infection. MEASURES: Identification of hMPV was realized on nasal swab samples by RT-PCR. RESULTS: Seventy-eight older people were resident at the time of the outbreak. Three of the 4 tested were positive for hMPV by RT-PCR and negative for 13 other viruses or bacteria. All probable infected residents presented cough; other symptoms were scarcer. An inflammatory response was present, with median C-reactive protein at 50 mg/L. The median duration of the illness was 7 days. The rate of infection among residents was high (51%), with 5 hospitalizations (12.5%) and 1 death (2.5%). In multivariate analysis, vaccination against influenza virus appeared to emerge as associated with a probable hMPV infection, but this might be an artifact, as the proportion of unvaccinated residents was low (15%). A clear infected population profile was hard to define, although limited autonomy and low ADL score may play a role. Basic hygiene precautions were reinforced, but droplet precautions seemed difficult to apply rigorously to this population. CONCLUSIONS/IMPLICATIONS: Clinical and biological presentations were nonspecific. The rate of infection was high, highlighting the need for the rapid introduction of strict precautions to contain the infection.
has issue date	2019-05-14(xsd:dateTime)
bibo:doi	10.1016/j.jamda.2019.03.015
bibo:pmid	31101588
has license	no-cc
sha1sum (hex)	51493b0b75744eb4c140824fe17b1d83c6c5b172
schema:url	https://doi.org/10.1016/j.jamda.2019.03.015
resource representing a document's title	Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective
has PubMed Central identifier	PMC7105973
has PubMed identifier	31101588
schema:publication	J Am Med Dir Assoc
resource representing a document's body	covid:51493b0b75744eb4c140824fe17b1d83c6c5b172#body_text
is schema:about of	named entity 'RETROSPECTIVE' named entity 'HOME PREVENTION' named entity 'OUTBREAK' named entity 'CONTROLLED STUDY' named entity 'describe' named entity 'Objectives' named entity 'OUTBREAK' named entity 'PARTICIPANTS' named entity 'NURSING HOME' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'FRENCH' named entity 'DESIGN' named entity 'TO DESCRIBE' named entity 'S T' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'CASE' named entity 'RISK FACTORS' named entity 'METAPNEUMOVIRUS' named entity 'TO IDENTIFY' named entity 'ASSOCIATED WITH' named entity 'PERSPECTIVE' named entity 'CLINICAL' named entity 'CLINICAL INFECTION' named entity 'NURSING HOME' named entity 'ADULTS' named entity 'OBJECTIVES' named entity 'SETTING' named entity 'study' named entity 'Nursing Home' named entity 'controlled study' named entity 'older adults' named entity 'metapneumovirus' named entity 'Nursing Home' named entity 'metapneumovirus' named entity 'human metapneumovirus' named entity 'NHs' named entity 'erythematous' named entity 'public health' named entity 'bacterial pneumonia' named entity 'infection' named entity 'RT-PCR' named entity 'infectious agents' named entity 'clinical features' named entity 'immunization schedule' named entity 'health care workers' named entity 'bacterial infection' named entity 'Rapid tests' named entity 'severe respiratory failure' named entity 'long-term care facilities' named entity 'body mass index' named entity 'infection' named entity 'health care workers' named entity 'clavulanic acid' named entity 'antibiotic therapy' named entity 'health care' named entity '2001 in the Netherlands' named entity 'nursing home' named entity 'influenza vaccination' named entity 'chi-square test' named entity 'general population' named entity 'rates of infection' named entity 'Streptococcus pneumoniae' named entity 'coinfections' named entity 'incubation period' named entity 'Gastrointestinal symptoms' named entity 'hRSV' named entity 'infection' named entity '7.5' named entity 'vaccination' named entity 'ceftriaxone' named entity 'rehabilitation center' named entity 'neutrophil' named entity 'older adults' named entity 'leukocyte'

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