About: Stimuli‐Responsive Biomaterials for Vaccines and Immunotherapeutic Applications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Stimuli‐Responsive Biomaterials for Vaccines and Immunotherapeutic Applications
Creator	Bolandparvaz, Amir Lewis, Jamal Pacifici, Noah
Source	Medline; PMC
abstract	The immune system is the key target for vaccines and immunotherapeutic approaches aimed at blunting infectious diseases, cancer, autoimmunity, and implant rejection. However, systemwide immunomodulation is undesirable due to the severe side effects that typically accompany such strategies. In order to circumvent these undesired, harmful effects, scientists have turned to tailorable biomaterials that can achieve localized, potent release of immune‐modulating agents. Specifically, “stimuli‐responsive” biomaterials hold a strong promise for delivery of immunotherapeutic agents to the disease site or disease‐relevant tissues with high spatial and temporal accuracy. This review provides an overview of stimuli‐responsive biomaterials used for targeted immunomodulation. Stimuli‐responsive or “environmentally responsive” materials are customized to specifically react to changes in pH, temperature, enzymes, redox environment, photo‐stimulation, molecule‐binding, magnetic fields, ultrasound‐stimulation, and electric fields. Moreover, the latest generation of this class of materials incorporates elements that allow for response to multiple stimuli. These developments, and other stimuli‐responsive materials that are on the horizon, are discussed in the context of controlling immune responses.
has issue date	2020-08-02(xsd:dateTime)
bibo:doi	10.1002/adtp.202000129
bibo:pmid	32838028
has license	no-cc
sha1sum (hex)	513c76240a24348781ba60424d442c1cd5a18992
schema:url	https://doi.org/10.1002/adtp.202000129
resource representing a document's title	Stimuli‐Responsive Biomaterials for Vaccines and Immunotherapeutic Applications
has PubMed Central identifier	PMC7435355
has PubMed identifier	32838028
schema:publication	Adv Ther (Weinh)
resource representing a document's body	covid:513c76240a24348781ba60424d442c1cd5a18992#body_text
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