About: Herpes Simplex Virus-1 Fine-Tunes Host’s Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Herpes Simplex Virus-1 Fine-Tunes Host’s Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Herpes Simplex Virus-1 Fine-Tunes Host’s Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models
Creator	Shukla, Deepak Yakoub, Abraam
Source	PMC
abstract	Herpes simplex virus-1 (HSV-1) infection causes severe conditions, with serious complications, including corneal blindness from uncontrolled ocular infections. An important cellular defense mechanism against HSV-1 infection is autophagy. The autophagic response of the host cell was suggested to be regulated by HSV-1. In this study, we performed a detailed analysis of autophagy in multiple HSV-1-targeted cell types, and under various infection conditions that recapitulate a productive infection model. We found that autophagy was slightly inhibited in one cell type, while in other cell types autophagy maintained its basal levels mostly unchanged during productive infection. This study refines the concept of HSV-1-mediated autophagy regulation to imply either inhibition, or prevention of activation, of the innate immune pathway.
has issue date	2015-04-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0124646
bibo:pmid	25894397
has license	cc-by
sha1sum (hex)	50ff548ec63f21fdb34fbdfe8fab41141c65fcb5
schema:url	https://doi.org/10.1371/journal.pone.0124646
resource representing a document's title	Herpes Simplex Virus-1 Fine-Tunes Host’s Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models
has PubMed Central identifier	PMC4403807
has PubMed identifier	25894397
schema:publication	PLoS One
resource representing a document's body	covid:50ff548ec63f21fdb34fbdfe8fab41141c65fcb5#body_text
is schema:about of	named entity 'inhibition' named entity 'levels' named entity 'suggested' named entity 'ocular' named entity 'Models' named entity 'RESPONSE' named entity 'MODELS' named entity 'PREVENTION OF' named entity 'BASAL' covid:arg/50ff548ec63f21fdb34fbdfe8fab41141c65fcb5 named entity 'COMPLICATIONS' named entity 'DETAILED' named entity 'MULTIPLE' named entity 'CONDITIONS' named entity 'INHIBITION' named entity 'ACTIVATION' named entity 'UNCONTROLLED' named entity 'HOST' named entity 'PRODUCTIVE' named entity 'INFECTION' named entity 'VARIOUS' named entity 'INCLUDING' named entity 'RESPONSE TO' named entity 'HERPES SIMPLEX VIRUS-1' named entity '27S' named entity 'AUTOPHAGY' named entity 'ANALYSIS' named entity 'UNCHANGED' named entity 'INFECTION' named entity 'HSV' named entity 'PERFORMED' named entity 'LEVELS' named entity 'MAINTAINED' named entity 'IMPORTANT' named entity 'EITHER' named entity 'IMMUNE' named entity 'SLIGHTLY' named entity 'CAUSES' named entity 'CELLULAR' named entity 'CORNEAL' named entity 'ITS' named entity 'INHIBITED' named entity 'ONE CELL TYPE' named entity 'REGULATED' named entity 'HOST CELL' named entity 'DEFENSE MECHANISM' named entity 'PATHWAY' named entity 'BLINDNESS' named entity 'FOUND' named entity 'TARGETED' named entity 'HSV-1 INFECTION' named entity 'PRODUCTIVE' named entity 'REGULATION' named entity 'CELL TYPES' named entity 'STUDY' named entity 'SEVERE' named entity 'COMPREHENSIVE ANALYSIS' named entity 'INFECTION MODEL' named entity 'OCULAR INFECTIONS' named entity 'CONCEPT' named entity 'FINE' named entity 'HERPES SIMPLEX VIRUS-1' named entity 'HSV-1' named entity 'activation' named entity 'innate immune' named entity 'multiple' named entity 'HSV-1 infection' named entity 'HSV-1' named entity 'basal' named entity 'study' named entity 'This' named entity 'host' named entity 'Infection' named entity 'cell type' named entity 'HSV-1 infection' named entity 'autophagy' named entity 'infection' named entity 'HSV' named entity 'Herpes simplex virus' named entity 'host cell'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software