About: Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals
Creator	Kohl, Alain Zmurko, Joanna Armstrong, Alison Clayton, Reginald Donald, Claire Mckee, Marian Vasey, Douglas
Source	Medline; PMC
abstract	Ensuring the virological safety of biologicals is challenging due to the risk of viral contamination of raw materials and cell banks, and exposure during in-process handling to known and/or emerging viral pathogens. Viruses may contaminate raw materials and biologicals intended for human or veterinary use and remain undetected until appropriate testing measures are employed. The outbreak and expansive spread of the mosquito-borne flavivirus Zika virus (ZIKV) poses challenges to screening human- and animal -derived products used in the manufacture of biologicals. Here, we report the results of an in vitro study where detector cell lines were challenged with African and Asian lineages of ZIKV. We demonstrate that this pathogen is robustly detectable by in vitro assay, thereby providing assurance of detection of ZIKV, and in turn underpinning the robustness of in vitro virology assays in safety testing of biologicals.
has issue date	2017-12-14(xsd:dateTime)
bibo:doi	10.1099/jgv.0.000995
bibo:pmid	29239715
has license	cc-by
sha1sum (hex)	50f74fde0ed19bb067b5a48ae60a6d00354b1ba7
schema:url	https://doi.org/10.1099/jgv.0.000995
resource representing a document's title	Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals
has PubMed Central identifier	PMC5882083
has PubMed identifier	29239715
schema:publication	J Gen Virol
resource representing a document's body	covid:50f74fde0ed19bb067b5a48ae60a6d00354b1ba7#body_text
is schema:about of	named entity 'virological' named entity 'biologicals' named entity 'MANUFACTURE' named entity 'IN VITRO ASSAY' named entity 'DUE TO' named entity 'VIROLOGY' named entity 'DETECTOR' named entity 'RAW MATERIALS' named entity 'EMPLOYED' named entity 'RESULTS' named entity 'SCREENING' named entity 'DETECTABLE' named entity 'VIRUSES' named entity 'RAW MATERIALS' named entity 'CELL' named entity 'VIRAL PATHOGENS' named entity 'RISK OF' named entity 'TESTING' named entity 'PATHOGEN' named entity 'BANKS' named entity 'REPORT' named entity 'CONTAMINATION' named entity 'MEASURES' named entity 'ZIKA VIRUS' named entity 'CHALLENGES' named entity 'BORNE' named entity 'IN VITRO' named entity 'HERE' named entity 'USE' named entity 'WHERE' named entity 'BIOLOGICALS' named entity 'CONTAMINATE' named entity 'ASSURANCE' named entity 'PROVIDING' named entity 'PROCESS' named entity 'APPROPRIATE' named entity 'ZIKA VIRUS' named entity 'ASIAN' named entity 'INTENDED' named entity 'RISK OF' named entity 'HUMAN' named entity 'TURN' named entity 'MANUFACTURE' named entity 'OUTBREAK' named entity 'VIROLOGICAL' named entity 'DETECTION' named entity 'MOSQUITO' named entity 'PRODUCTS' named entity 'USED' named entity 'SAFETY' named entity 'CELL LINES' named entity 'HANDLING' named entity 'DERIVED' named entity 'VETERINARY' named entity 'ANIMAL' named entity 'AFRICAN' named entity 'SPREAD' named entity 'VIRUS CONTAMINATION' named entity 'CELL LINES' named entity 'EXPOSURE' named entity 'KNOWN' named entity 'BIOLOGICALS' named entity 'IN VITRO STUDY' named entity 'VIRAL' named entity 'FLAVIVIRUS' named entity 'Zika virus' named entity 'biologicals' named entity 'Viruses' named entity 'detectable' named entity 'assurance' named entity 'Zika virus' named entity 'manufacture' named entity 'biologicals' named entity 'raw materials' named entity 'virus'

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