About: Role of Host Immune Response and Viral Load in the Differential Outcome of Pandemic H1N1 (2009) Influenza Virus Infection in Indian Patients

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About: Role of Host Immune Response and Viral Load in the Differential Outcome of Pandemic H1N1 (2009) Influenza Virus Infection in Indian Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Role of Host Immune Response and Viral Load in the Differential Outcome of Pandemic H1N1 (2009) Influenza Virus Infection in Indian Patients
Creator	Kadam, Deelip Arankalle, Vidya Arya, Ravi Chadha, Mandeep Lole, Kavita Ramdasi, Ashwini Sangle, Shashi Tripathy, Anuradha
source	PMC
abstract	BACKGROUND: An unusually high number of severe pneumonia cases with considerable mortality is being observed with the pandemic H1N1 2009 virus infections globally. In India, all mild as well as critically ill cases were admitted and treated in the government hospitals during the initial phase of the pandemic. The present study was undertaken during this early phase of the pandemic. METHODOLOGY: The role of viral load and host factors in the pathogenesis were assessed by examining 26 mild (MP), 15 critically ill patients (CIP) and 20 healthy controls from Pune, India. Sequential blood and lung aspirate samples were collected from CIP. Viral load and cytokines/chemokine levels were determined from the plasma and lung aspirates of the patients. TLR levels were determined by staining and FACS analysis. Gene profiling was done for both cells in the lung aspirates and PBMCs using TaqMan Low Density arrays. Antibody titres and isotyping was done using HA protein based ELISAs. PRINCIPAL FINDINGS: 13/15 critically ill patients expired. All plasma samples were negative for the virus irrespective of the patient's category. Sequential lung samples from CIP showed lower viral loads questioning association of viral replication with the severity. Anti-rpH1N1-09-HA-IgG titres were significantly higher in critically ill patients and both categories circulated exclusively IgG1 isotype. Critically ill patients exhibited increase in TLR-3, 4, 7 and decrease in TLR-2 expressions. The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10. Majority of the immune-function genes were down-regulated in the PBMCs and up-regulated in the cells from lung aspirates of critically ill patients. No distinct pattern differentiating fatal and surviving patients was observed when sequential samples were examined for various parameters. CONCLUSIONS: Disease severity was associated with pronounced impairment of host immune response.
has issue date	2010-10-01(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0013099
bibo:pmid	20957032
has license	cc-by
sha1sum (hex)	50e55ab8dd87f7523b7f25203ef10004c8d3b13e
schema:url	https://doi.org/10.1371/journal.pone.0013099
resource representing a document's title	Role of Host Immune Response and Viral Load in the Differential Outcome of Pandemic H1N1 (2009) Influenza Virus Infection in Indian Patients
has PubMed Central identifier	PMC2948498
has PubMed identifier	20957032
schema:publication	PLoS One
resource representing a document's body	covid:50e55ab8dd87f7523b7f25203ef10004c8d3b13e#body_text
is schema:about of	named entity 'INFLUENZA VIRUS' named entity 'infections' named entity 'phase' named entity 'observed' named entity 'Differential' named entity 'INDIAN' named entity 'TREATED' named entity 'MILD' named entity 'PANDEMIC' named entity 'PANDEMIC' named entity 'VIRAL LOAD' named entity 'H1N1' named entity 'INITIAL PHASE' named entity 'EARLY' named entity 'BEING' named entity 'GLOBALLY' covid:arg/50e55ab8dd87f7523b7f25203ef10004c8d3b13e named entity 'CASES' named entity 'ROLE' named entity 'OUTCOME' named entity 'DIFFERENTIAL' named entity 'HOST IMMUNE RESPONSE' named entity 'CRITICALLY ILL' named entity 'PRESENT' named entity 'INFECTIONS' named entity 'UNUSUALLY HIGH' named entity 'PHASE' named entity 'VIRUS INFECTION' named entity 'H1N1' named entity 'PATIENTS' named entity 'SEVERE PNEUMONIA' named entity 'MORTALITY' named entity 'NUMBER OF' named entity 'OBSERVED' named entity 'CONSIDERABLE' named entity 'GOVERNMENT' named entity 'INDIA' named entity 'VIRUS' named entity 'STUDY' named entity 'ADMITTED' named entity 'BACKGROUND' named entity 'HOSPITALS' named entity 'pandemic' named entity 'virus' named entity 'H1N1' named entity 'Viral' named entity 'severe pneumonia' named entity 'Infection' named entity 'H1N1' named entity 'Viral Load' named entity 'plasma' named entity 'CCL4' named entity 'antibodies' named entity 'TNFA' named entity 'plasma' named entity 'critically ill patients' named entity 'blood samples' named entity 'Pune' named entity 'IL6' named entity 'CCL4' named entity 'lung' named entity 'downregulation' named entity 'cytokines' named entity 'gene expression' named entity 'IL10' named entity 'critically ill' named entity 'Lung aspirate' named entity 'infection' named entity 'antibody' named entity 'inflammatory cytokines' named entity 'gene expression' named entity 'H5N1' named entity 'weight loss' named entity 'categorical data'

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