About: Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family

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About: Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family
Creator	Ballesteros, Angela Tami, Cecilia Casasnovas, José Kaplan, Gerardo Martínez-Muñ Oz, Laura Santiago, Cé
Source	Elsevier; Medline; PMC
abstract	The T cell immunoglobulin mucin (TIM) receptors are involved in the regulation of immune responses, autoimmunity, and allergy. Structures of the N-terminal ligand binding domain of the murine mTIM-1 and mTIM-2 receptors revealed an immunoglobulin (Ig) fold, with four Cys residues bridging a distinctive CC′ loop to the GFC β-sheet. The structures showed two ligand-recognition modes in the TIM family. The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding. Biochemical, mutational, and cell adhesion analyses confirmed the divergent ligand-binding modes revealed by the structures. Structural features characteristic of mTIM-1 appear conserved in human TIM-1, which also mediated homophilic interactions. The extracellular mucin domain enhanced binding through the Ig domain, modulating TIM receptor functions. These results explain the divergent immune functions described for the murine receptors and the role of TIM-1 as a cell adhesion receptor in renal regeneration and cancer.
has issue date	2007-03-23(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2007.01.014
bibo:pmid	17363299
has license	no-cc
sha1sum (hex)	50dcda1d36e6c9b8e0f4d0640b6ef75769337a03
schema:url	https://doi.org/10.1016/j.immuni.2007.01.014
resource representing a document's title	Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family
has PubMed Central identifier	PMC7111020
has PubMed identifier	17363299
schema:publication	Immunity
resource representing a document's body	covid:50dcda1d36e6c9b8e0f4d0640b6ef75769337a03#body_text
is schema:about of	named entity 'REVEAL' named entity 'fold' named entity 'family' named entity 'renal' named entity 'allergy' named entity 'regulation' named entity 'T Cell' named entity 'IMMUNOGLOBULIN' named entity 'RECEPTORS' named entity 'STRUCTURAL' named entity 'CYS' named entity 'RESULTS' named entity 'FOLD' named entity 'FORMED' named entity 'FEATURES' named entity 'IDENTIFIED' named entity 'DESCRIBED' named entity 'STRUCTURES' named entity 'N-TERMINAL ' named entity 'CONFIRMED' named entity 'EXTRACELLULAR' named entity 'LIGAND-BINDING' named entity 'STRUCTURE' named entity 'LIGAND BINDING DOMAIN' named entity 'IMMUNE' named entity 'MTIM' named entity 'CHARACTERISTIC' named entity 'LIGAND' named entity 'BIOCHEMICAL' named entity 'HOMOPHILIC' named entity 'MURINE' named entity 'STRUCTURES' named entity 'CONSERVED' named entity 'INVOLVED' named entity 'RENAL REGENERATION' named entity 'FAMILY' named entity 'IMMUNOGLOBULIN' named entity 'A CELL' named entity 'DOMAIN' named entity 'ROLE' named entity 'THESE' named entity 'REGULATION' named entity 'HUMAN' named entity 'REVEALED' named entity 'FAMILY' named entity 'ALLERGY' named entity 'MUCIN' covid:arg/50dcda1d36e6c9b8e0f4d0640b6ef75769337a03 named entity 'INTERACTIONS' named entity 'INTERACTION' named entity 'RECOGNITION' named entity 'T CELL' named entity 'IMMUNE RESPONSES' named entity 'RECEPTORS' named entity 'APPEAR' named entity 'BRIDGING' named entity 'IMMUNE RESPONSES' named entity 'FUNCTIONS' named entity 'SHEET' named entity 'LOOP' named entity 'BINDING' named entity 'CANCER' named entity 'CELL ADHESION RECEPTOR' named entity 'TIM' named entity 'MEDIATED' named entity 'RECEPTOR' named entity 'AUTOIMMUNITY' named entity 'T CELL' named entity 'DIMER' named entity 'ADHESION' named entity 'CELL ADHESION' named entity 'MECHANISMS' named entity 'TIM' named entity 'RECEPTOR' named entity 'TIM-1' named entity 'MUCIN'

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