About: Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study

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About: Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study
Creator	Wang, Zhen Chen, Xiaorong Lu, Yunfei Yang, Zongguo Xu, Hua Zhou, Han Chen, Haiying Liu, Y Tang, H Zhang, Tianhong Li, J Zhang, H Chen, X Yang, Y Hu, Hao Guo, Qian Liu, Xiaohua Chen, Y Wang, H Xu, J Zheng, Y Li, G Shi, J Xu, X Yang, Z Zhou, S Hu, X Shi, Jia Wang, Jijun Fromson, John Li, Chunbo Li, Guanjun Tang, Yingying Wang, Xiaoliang Xu, Yong Yang, Shuwen Zheng, Yuchen Guo, Q Lu, T
Source	Elsevier; Medline; PMC
abstract	Since the end of 2019, Corona Virus Disease 2019 (COVID-19) has been the cause of a worldwide pandemic. The mental status of patients with COVID-19 who have been quarantined and the interactions between their psychological distress and physiological levels of inflammation have yet to be analyzed. Using a mixed-method triangulation design (QUAN + QUAL), this study investigated and compared the mental status and inflammatory markers of 103 patients who, while hospitalized with mild symptoms, tested positive with COVID-19 and 103 matched controls that were COVID-19 negative. The severity of depression, anxiety, and post-traumatic stress symptoms (PTSS) was measured via an on-line survey. Using a convenience sampling technique, qualitative data were collected until the point of data saturation. In addition, a semi-structured interview was conducted among five patients with COVID-19. Peripheral inflammatory markers were also collected in patients, both at baseline and within ± three days of completing the on-line survey. Results revealed that COVID-19 patients, when compared to non-COVID controls, manifested higher levels of depression (P < 0.001), anxiety (P < 0.001), and post-traumatic stress symptoms (P < 0.001). A gender effect was observed in the score of “Perceived Helplessness”, the subscale of PSS-10, with female patients showing higher scores compared to male patients (Z = 2.56, P = 0.010), female (Z = 2.37, P = 0.018) and male controls (Z = 2.87, P = 0.004). Levels of CRP, a peripheral inflammatory indicator, correlated positively with the PHQ-9 total score (R = .37, P = 0.003, Spearman’s correlation) of patients who presented symptoms of depression. Moreover, the change of CRP level from baseline inversely correlated with the PHQ-9 total score (R = -0.31, P = 0.002), indicative of improvement of depression symptoms. Qualitative analysis revealed similar results with respect to patient reports of negative feelings, including fear, guilt, and helplessness. Stigma and uncertainty of viral disease progression were two main concerns expressed by COVID-19 patients. Our results indicate that significant psychological distress was experienced by hospitalized COVID-19 patients and that levels of depressive features may be related to the inflammation markers in these patients. Thus, we recommend that necessary measures should be provided to address depression and other psychiatric symptoms for COVID-19 patients and attention should be paid to patient perceived stigma and coping strategies when delivering psychological interventions.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1016/j.bbi.2020.05.038
bibo:pmid	32416290
has license	no-cc
sha1sum (hex)	50d61e2d02d4ce946a82f473eb9a4af12b8ab9a7
schema:url	https://doi.org/10.1016/j.bbi.2020.05.038
resource representing a document's title	Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study
has PubMed Central identifier	PMC7235603
has PubMed identifier	32416290
schema:publication	Brain Behav Immun
resource representing a document's body	covid:50d61e2d02d4ce946a82f473eb9a4af12b8ab9a7#body_text
is schema:about of	covid:arg/50d61e2d02d4ce946a82f473eb9a4af12b8ab9a7 named entity 'mental status' named entity 'psychological distress' named entity 'inflammation' named entity 'psychological distress' named entity 'IL-2R' named entity 'COVID' named entity 'blood samples' named entity 'major depression' named entity 'CRP' named entity 'neutrophil' named entity 'Shenzhen' named entity 'People's Republic of China' named entity 'inflammatory response' named entity 'psychological assessments' named entity 'PTSD' named entity 'psychological distress' named entity 'PTSD' named entity 'correlation' named entity 'Hubei' named entity 'CRP' named entity 'depression' named entity 'PHQ-9' named entity 'procalcitonin' named entity 'Shenzhen' named entity 'socio-economic' named entity 'anxiety' named entity 'COVID' named entity 'Sysmex' named entity 'depression' named entity 'intrusive symptoms' named entity 'social desirability' named entity 'DSM-5' named entity 'Inflammatory agents' named entity 'correlation' named entity 'PHQ-9' named entity 'Chi-square tests' named entity 'COVID' named entity 'psychopathology' named entity 'infection' named entity 'mental status' named entity 'depression' named entity '5.52'

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