About: Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study

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About: Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study
Creator	Schrappe, Martin Martin, A Beier, Rita Grigull, Lorenz Kidas, Ekaterini Ae, Möricke Ae, Stanulla Ae, Welte Anja, A Karl, A
Source	PMC
abstract	Specific mutations of the TNF-alpha (TNF-α) and Lymphotoxin-alpha (LT-α) genes are correlated to the outcome of patients during serious infections. This study aimed at correlating these polymorphisms to lethal infections during childhood acute lymphoblastic leukemia (ALL). A matched case-control study of 34 patients who died due to infections during ALL treatment and 68 ALL patients without lethal infections was performed. Genomic DNA was isolated from blood smears and specific fragments including the polymorphic site of each gene were amplified. In the total study population, 23/102 (22.5%) of the children carried at least two variant alleles (high-producer haplotype). The variant genotypes were equally distributed between cases and controls [relative risk (RR) 1.17 (CI 0.33–2.22, P = 0.752)]. With regard to infective organisms, no statistically significant differences could be detected between the groups for bacterial infections [RR 1.59 (CI 0.56–4.50), P 0.379]. Patients with a LT-α (10.5 kb/5.5 kb; 5.5 kb/5.5 kb) haplotype, however, seemed to have a significant higher risk of attracting a lethal infection during induction/consolidation chemotherapy (RR 2.98, CI 0.98–9.01, P = 0.05). These results support a role of specific genetic polymorphisms on lethal infections during induction chemotherapy of ALL treatment.
has issue date	2009-04-08(xsd:dateTime)
bibo:doi	10.1007/s12185-009-0285-6
bibo:pmid	19353239
has license	no-cc
sha1sum (hex)	508e3a20a241de232f206cd262cbc87caefc2cbe
schema:url	https://doi.org/10.1007/s12185-009-0285-6
resource representing a document's title	Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study
has PubMed Central identifier	PMC7102140
has PubMed identifier	19353239
schema:publication	Int J Hematol
resource representing a document's body	covid:508e3a20a241de232f206cd262cbc87caefc2cbe#body_text
is schema:about of	named entity 'infective' named entity 'induction chemotherapy' named entity 'TNF-a' named entity 'genotypes' named entity 'risk' named entity 'DETECTED' named entity 'SUPPORT' named entity 'SIGNIFICANT' named entity 'ATTRACTING' named entity 'CHEMOTHERAPY' named entity 'CONTROLS' named entity 'TREATMENT' named entity 'INCLUDING' named entity 'INFECTIONS' named entity 'gene' named entity 'infections' named entity 'haplotype' named entity 'groups' named entity 'support' named entity 'lethal' named entity 'infections' named entity 'lethal' named entity 'relative risk' named entity 'statistically significant' named entity 'induction chemotherapy' named entity 'polymorphic' named entity 'study population' named entity 'polymorphisms' named entity 'genotypes' named entity 'case-control study' named entity 'bacterial infections' named entity 'genetic polymorphisms' named entity 'blood smears' named entity 'alleles' named entity 'chemotherapy' named entity 'lethal' named entity 'relative risk' named entity 'matched-pair analysis' named entity 'allele' named entity 'TNF-a' named entity 'homozygous' named entity 'polymorphism' named entity 'TNF' named entity 'allele' named entity 'alveolar' named entity 'risk group' named entity 'control subjects' named entity 'homozygous' named entity 'critically ill patients' named entity 'multicenter trial' named entity 'life-threatening' named entity 'SAS' named entity 'polymorphisms' named entity 'genotype' named entity 'TNF-a' named entity 'genetic analyses' named entity 'haplotypes' named entity '1, 2' named entity 'relapse' named entity 'genotypes' named entity 'autoimmune' named entity 'infection' named entity 'severe sepsis' named entity 'genetic polymorphism' named entity 'homozygous' named entity 'restriction site' named entity 'alleles' named entity 'parenteral nutrition' named entity '3, 4' named entity 'Genetic polymorphisms' named entity 'body temperature' named entity 'Cary, NC'

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