About: Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral Infection

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About: Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral Infection
Creator	Farrugia, Fanny Gonzalez-Dunia, Daniel Le Masson, Gwendal Liblau, Roland Martin-Blondel, Guillaume Suberbielle, Elsa Goire Chevalier, Gré Line Monnet, Cé Rie Duplan, Valé
Source	Medline; PMC
abstract	Following infection of the central nervous system (CNS), the immune system is faced with the challenge of eliminating the pathogen without causing significant damage to neurons, which have limited capacities of renewal. In particular, it was thought that neurons were protected from direct attack by cytotoxic T lymphocytes (CTL) because they do not express major histocompatibility class I (MHC I) molecules, at least at steady state. To date, most of our current knowledge on the specifics of neuron-CTL interaction is based on studies artificially inducing MHC I expression on neurons, loading them with exogenous peptide and applying CTL clones or lines often differentiated in culture. Thus, much remains to be uncovered regarding the modalities of the interaction between infected neurons and antiviral CD8 T cells in the course of a natural disease. Here, we used the model of neuroinflammation caused by neurotropic Borna disease virus (BDV), in which virus-specific CTL have been demonstrated as the main immune effectors triggering disease. We tested the pathogenic properties of brain-isolated CD8 T cells against pure neuronal cultures infected with BDV. We observed that BDV infection of cortical neurons triggered a significant up regulation of MHC I molecules, rendering them susceptible to recognition by antiviral CTL, freshly isolated from the brains of acutely infected rats. Using real-time imaging, we analyzed the spatio-temporal relationships between neurons and CTL. Brain-isolated CTL exhibited a reduced mobility and established stable contacts with BDV-infected neurons, in an antigen- and MHC-dependent manner. This interaction induced rapid morphological changes of the neurons, without immediate killing or impairment of electrical activity. Early signs of neuronal apoptosis were detected only hours after this initial contact. Thus, our results show that infected neurons can be recognized efficiently by brain-isolated antiviral CD8 T cells and uncover the unusual modalities of CTL-induced neuronal damage.
has issue date	2011-11-17(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1002393
bibo:pmid	22114563
has license	cc-by
sha1sum (hex)	5016b361dce58077b3d647b0772425e079f98d8d
schema:url	https://doi.org/10.1371/journal.ppat.1002393
resource representing a document's title	Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral Infection
has PubMed Central identifier	PMC3219726
has PubMed identifier	22114563
schema:publication	PLoS Pathog
resource representing a document's body	covid:5016b361dce58077b3d647b0772425e079f98d8d#body_text
is schema:about of	named entity 'isolated' named entity 'pathogen' named entity 'pathogenic' named entity 'induced' named entity 'regulation' named entity 'Borna' named entity 'neurons' named entity 'inducing' named entity 'central nervous system (CNS)' named entity 'triggering' named entity 'VIRAL INFECTION' named entity 'TRIGGERING' named entity 'MAIN' named entity 'CHALLENGE' named entity 'NEURONS' named entity 'ANALYZED' named entity 'LOADING' named entity 'PATHOGEN' named entity 'CTL' named entity 'PURE' named entity 'IMMUNE' named entity 'CD8' named entity 'CURRENT' named entity 'HISTOCOMPATIBILITY' named entity 'STUDIES' named entity 'CULTURE' named entity 'DIFFERENTIATED' named entity 'ANTIVIRAL' named entity 'NEURONAL' named entity 'ELECTRICAL ACTIVITY' named entity 'HERE' named entity 'SUSCEPTIBLE' named entity 'INITIAL' named entity 'CORTICAL' named entity 'FACED' named entity 'NATURAL' named entity 'CAUSING' named entity 'ATTACK' named entity 'T LYMPHOCYTES' named entity 'RENDERING' named entity 'DEPENDENT' named entity 'INDUCING' named entity 'INTERACTION' named entity 'DAMAGE' named entity 'APPLYING' named entity 'RELATIONSHIPS' named entity 'MOST OF' named entity 'PROPERTIES' named entity 'INFECTION' named entity 'CONTACTS' named entity 'REAL-TIME IMAGING' named entity 'USED' named entity 'PARTICULAR' named entity 'NEURONAL DAMAGE' named entity 'SIGNIFICANT' named entity 'MORPHOLOGICAL' named entity 'CLASS I' named entity 'OBSERVED' named entity 'IMMUNE SYSTEM' named entity 'CLONES' named entity 'SIGNS' named entity 'DATE' named entity 'NEUROTROPIC' named entity 'NEUROTROPIC' named entity 'MUCH' named entity 'CHANGES' named entity 'IMPAIRMENT' named entity 'RAPID' named entity 'BASED' named entity 'DISEASE' named entity 'MODALITIES' named entity 'UNCOVERED' named entity 'LIMITED'

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